0000000001096583
AUTHOR
Olga Villarroya
Morphological alterations in the hippocampus of the Ts65Dn mouse model for Down syndrome correlate with structural plasticity markers
Down syndrome (DS) is the most common chromosomal aneuploidy. Although trisomy on chromosome 21 can display variable phenotypes, there is a common feature among all DS individuals: the presence of intellectual disability. This condition is partially attributed to abnormalities found in the hippocampus of individuals with DS and in the murine model for DS, Ts65Dn. To check if all hippocampal areas were equally affected in 4-5 month adult Ts65Dn mice, we analysed the morphology of dentate gyrus granule cells and cornu ammonis pyramidal neurons using Sholl method on Golgi-Cox impregnated neurons. Structural plasticity has been analysed using immunohistochemistry for plasticity molecules follow…
Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice.
The balance between synthesis and degradation of the cartilage extracellular matrix is severely altered in osteoarthritis, where degradation predominates. One reason for this imbalance is believed to be due to the ligation of the α5β1 integrin, the classic fibronectin (FN) receptor, with soluble FN fragments instead of insoluble FN fibrils, which induces matrix metalloproteinase (MMP) expression. Our objective was to determine whether the lack of α5β1-FN binding influences cartilage morphogenesis in vivo and whether non-ligated α5β1 protects or aggravates the course of osteoarthritis in mice. We engineered mice (Col2a-Cre;Fn1RGE/fl), whose chondrocytes express an α5β1 binding-deficient FN, …
Alteración en los circuitos inhibidores en corteza somatosensorial e hipocampo en el modelo murino de síndrome de Down Ts65Dn
El síndrome de Down, con una incidencia de uno de cada 1000 nacimientos vivos, es la alteración genética más común asociada con retraso mental. La trisomía del cromosoma 21 induce un fenotipo variable que presenta, entre otros, defectos cardíacos o desarrollo temprano de la enfermedad de Alzheimer pero cuyo único aspecto común es un cierto grado de retraso mental. El mecanismo que provoca este retraso no está totalmente elucidado. Existen evidencias que apuntan a defectos en la formación de redes neurales, alteraciones en el procesamiento de la información y/o defectos en la capacidad plástica del cerebro. A nivel celular se ha observado que los individuos con síndrome de Down presentan alt…