0000000001098742

AUTHOR

Angel Merchante

showing 3 related works from this author

Lipoprotein phenotype and insulin resistance in familial combined hyperlipidemia.

2001

The study objective was to investigate the relationship of insulin resistance (IR) with the lipoprotein phenotype in familial combined hyperlipidemia (FCH). Thirty-seven FCH men diagnosed by clinical and biochemical criteria and classified as lipoprotein phenotype IIa (n = 9), IIb (n = 17), or IV (n = 11) were compared with a healthy control group of 30 men of similar age, body mass index (BMI), waist to hip ratio (WHR), and systolic and diastolic blood pressure. In all subjects, the plasma lipoprotein profile and baseline and post-oral glucose tolerance test (OGTT) glucose and insulin plasma values were measured. An intravenous glucose tolerance test was performed and IR was studied by the…

AdultMalemedicine.medical_specialtyEndocrinology Diabetes and Metabolismmedicine.medical_treatmentLipoproteinsHyperlipidemia Familial CombinedEndocrinologyWaist–hip ratioInsulin resistanceReference ValuesInternal medicineInsulin SecretionmedicineHumansInsulinPancreatic hormoneHypertriglyceridemiaGlucose tolerance testmedicine.diagnostic_testChemistryInsulinHypertriglyceridemiaArea under the curveGlucose Tolerance TestMiddle Agedmedicine.diseaseEndocrinologyPhenotypeInsulin ResistanceLipoproteinMetabolism: clinical and experimental
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A study of insulin resistance using the minimal model in nondiabetic familial combined hyperlipidemic patients.

1998

The presence of insulin resistance in 20 male nondiabetic patients with familial combined hyperlipidemia (FCH) and 20 controls of similar age and body mass index (BMI) was investigated using the minimal model method modified by the administration of insulin and an oral glucose tolerance test. The peripheral sensitivity of insulin, expressed as the insulin sensitivity index (Si), was 1.91 ± 1.05 and 2.86 ± 1.19 × 10−4 · min−1 · mU/L in FCH patients and controls, respectively (P < .01), and the corresponding value for the peripheral utilization of glucose independently of insulin (Sg) was 1.70 ± 1.13 in FCH patients and 2.35 ± 0.60 × 10−2 · min−1 in controls (P < .02). In the FCH group, the S…

AdultBlood GlucoseMalemedicine.medical_specialtyEndocrinology Diabetes and Metabolismmedicine.medical_treatmentHyperlipidemia Familial CombinedFatty Acids NonesterifiedBody Mass IndexEndocrinologyWaist–hip ratioInsulin resistanceStatistical significanceInternal medicinemedicineDiabetes MellitusHumansInsulinObesityPancreatic hormoneTriglyceridesApolipoproteins Bbusiness.industryInsulinCholesterol HDLArea under the curveAge FactorsMiddle Agedmedicine.diseaseObesityEndocrinologyGlucoseCase-Control StudiesBody ConstitutionInsulin ResistancebusinessBody mass indexMetabolism: clinical and experimental
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Insulin resistance in patients with familial combined hyperlipidemia and coronary artery disease.

1997

The minimum model modified by the administration of insulin provides an objective and relatively easily measured index of peripheral sensitivity to insulin which was significantly lower (p <0.02) in familial combined hyperlipidemia (FCH) with ischemic heart disease (IHD) than in FCH without IHD and in control subjects (1.2 +/- 0.6, 1.9 +/- 1.0, 2.9 +/- 1.2 x 10(-4) mU/L/ min, respectively). In patients with FCH, insulin resistance explains, at least in part, their metabolic alterations (hypertension, abnormal glucose tolerance, hyperinsulinemia) and elevated IHD.

Blood GlucoseMalemedicine.medical_specialtymedicine.medical_treatmentLipoproteinsHyperlipidemia Familial CombinedCoronary DiseaseDiseaseCoronary artery diseaseInsulin resistanceRisk FactorsInternal medicineHyperinsulinemiaMedicineHumansInsulinIn patientcardiovascular diseasesbusiness.industryInsulinGlucose Tolerance TestMiddle Agedmedicine.diseasePeripheralPedigreeEndocrinologyPhenotypeCardiologyInsulin ResistanceCardiology and Cardiovascular MedicinebusinessLipoproteinThe American journal of cardiology
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