Author: E Morcillo

0000000001101034

AUTHOR

E Morcillo

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Haemodynamic effects of long-term administration of sildenafil in normotensive pregnant and non-pregnant rats

2011

Please cite this paper as: Pellicer B, Herraiz S, Cauli O, Rodrigo R, Asensi M, Cortijo J, Serra V, Morcillo E, Felipo V, Simon C, Pellicer A. Haemodynamic effects of long-term administration of sildenafil in normotensive pregnant and non-pregnant rats. BJOG 2011;118:615–623. Objective To determine the effects of chronic administration of sildenafil citrateon healthy pregnant rats. Design In vivo animal experimental study. Setting Fundacion IVI–Instituto Universitario IVI, Valencia, Spain. Sample Pregnant and non-pregnant Wistarrats exposed to chronic administration of sildenafil. Methods Placental cross-barrier and feto-maternal relationship levels, maternal blood pressure, and haemody…

medicine.medical_specialtyPregnancyFetusmedicine.drug_mechanism_of_actionSildenafilbusiness.industryBlood viscosityObstetrics and Gynecologymedicine.diseasechemistry.chemical_compoundEndocrinologymedicine.anatomical_structurechemistryInternal medicinecardiovascular systemmedicineVascular resistanceGestationbusinessPhosphodiesterase 5 inhibitorDuctus venosusBJOG: An International Journal of Obstetrics & Gynaecology

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