0000000001101229

AUTHOR

Christiane Knoth

showing 2 related works from this author

Macromol. Rapid Commun. 9-10/2011

2011

Polymers and PlasticsOrganic ChemistryMaterials ChemistryMacromolecular Rapid Communications
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HPMA Based Amphiphilic Copolymers Mediate Central Nervous Effects of Domperidone

2011

In this study we give evidence that domperidone encapsulated into amphiphilic p(HPMA)-co-p(laurylmethacrylate) (LMA) copolymer aggregates is able to cross the blood-brain barrier, since it affected motor behaviour in animals, which is a sensitive measure for CNS actions. Carefully designed copolymers based on the clinically approved p(HPMA) were selected and synthesized by a combination of controlled radical polymerization and post-polymerization modification. The hydrodynamic radii (R(h) ) of amphiphilic p(HPMA)-co-p(LMA) alone and loaded with domperidone were determined by fluorescence correlation spectroscopy.

Materials sciencePolymers and PlasticsStereochemistryOrganic ChemistryRadical polymerizationMotor behaviourDomperidoneAmphiphileMaterials ChemistrymedicineCopolymerBiophysicsCns activitymedicine.drugAmphiphilic copolymerMacromolecular Rapid Communications
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