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RESEARCH PRODUCT
HPMA Based Amphiphilic Copolymers Mediate Central Nervous Effects of Domperidone
Mirjam HemmelmannKaloian KoynovRudolf ZentelMatthias BarzMareli AllmerothChristiane KnothFrank RöschDorothea ModereggerUlrich SchmittChristoph Hiemkesubject
Materials sciencePolymers and PlasticsStereochemistryOrganic ChemistryRadical polymerizationMotor behaviourDomperidoneAmphiphileMaterials ChemistrymedicineCopolymerBiophysicsCns activitymedicine.drugAmphiphilic copolymerdescription
In this study we give evidence that domperidone encapsulated into amphiphilic p(HPMA)-co-p(laurylmethacrylate) (LMA) copolymer aggregates is able to cross the blood-brain barrier, since it affected motor behaviour in animals, which is a sensitive measure for CNS actions. Carefully designed copolymers based on the clinically approved p(HPMA) were selected and synthesized by a combination of controlled radical polymerization and post-polymerization modification. The hydrodynamic radii (R(h) ) of amphiphilic p(HPMA)-co-p(LMA) alone and loaded with domperidone were determined by fluorescence correlation spectroscopy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-04-05 | Macromolecular Rapid Communications |