0000000001101845
AUTHOR
R. Orru
Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein
JBC papers in press xx, 16604-16619 (2019). doi:10.1074/jbc.RA119.009845
IM30 IDPs form a membrane protective carpet upon super-complex disassembly
AbstractMembers of thephage shock protein A(PspA) family, including theinner membrane-associated protein of 30 kDa(IM30), are suggested to stabilize stressed cellular membranes. Furthermore, IM30 is essential in thylakoid membrane-containing chloroplasts and cyanobacteria, where it is involved in membrane biogenesis and/or remodeling. While it is well known that PspA and IM30 bind to membranes, the mechanism of membrane stabilization is still enigmatic. Here we report that ring-shaped IM30 super-complexes disassemble on membranes, resulting in formation of a membrane-protecting protein carpet. Upon ring dissociation, the C-terminal domain of IM30 unfolds, and the protomers self-assemble on …