0000000001102587

AUTHOR

Aurelia Gregori-romero

showing 1 related works from this author

Correlation between EGFR Amplification and the Expression of MicroRNA-200c in Primary Glioblastoma Multiforme

2014

Extensive infiltration of the surrounding healthy brain tissue is a critical feature in glioblastoma. Several miRNAs have been related to gliomagenesis, some of them related with the EGFR pathway. We have evaluated whole-genome miRNA expression profiling associated with different EGFR amplification patterns, studied by fluorescence in situ hybridization in tissue microarrays, of 30 cases of primary glioblastoma multiforme, whose clinicopathological and immunohistochemical features have also been analyzed. MicroRNA-200c showed a very significant difference between tumors having or not EGFR amplification. This microRNA plays an important role in epithelial-mesenchymal transition, but its impl…

Malelcsh:MedicineGene expressionGene duplicationMedicine and Health Scienceslcsh:ScienceNeurological TumorsIn Situ Hybridization FluorescenceMultidisciplinaryTissue microarraymedicine.diagnostic_testBrain NeoplasmsCancer Risk FactorsGliomaMiddle AgedCadherinsErbB ReceptorsGene Expression Regulation NeoplasticNeurologyOncologyImmunohistochemistryFemaleDNA microarrayResearch ArticleSignal TransductionEpithelial-Mesenchymal TransitionGenetic Causes of CancerBiologyYoung AdultmicroRNAmedicineGeneticsCancer GeneticsHumansEpithelial–mesenchymal transitionAgedHomeodomain Proteinslcsh:RGene AmplificationBiology and Life SciencesCancers and NeoplasmsZinc Finger E-box-Binding Homeobox 1Molecular biologySurvival AnalysisMicroRNAsTissue Array AnalysisGenetics of DiseaseCancer researchlcsh:QGlioblastomaGlioblastoma MultiformeFluorescence in situ hybridizationTranscription FactorsPLoS ONE
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