0000000001103036

AUTHOR

Andreas Charidimou

showing 6 related works from this author

Recanalization Therapies in Acute Ischemic Stroke Patients Impact of Prior Treatment With Novel Oral Anticoagulants on Bleeding Complications and Out…

2015

Background— We explored the safety of intravenous thrombolysis (IVT) or intra-arterial treatment (IAT) in patients with ischemic stroke on non-vitamin K antagonist oral anticoagulants (NOACs, last intake <48 hours) in comparison with patients (1) taking vitamin K antagonists (VKAs) or (2) without previous anticoagulation (no-OAC). Methods and Results— This is a multicenter cohort pilot study. Primary outcome measures were (1) occurrence of intracranial hemorrhage (ICH) in 3 categories: any ICH (ICH any ), symptomatic ICH according to the criteria of the European Cooperative Acute Stroke Study II (ECASS-II) (sICH ECASS-II ) and the National Institute of Neurological Disorders and Stroke …

MaleBrain Ischemia/blood/drug therapyVitamin Kmedicine.medical_treatmentendovascular proceduresAnticoagulants/administration & dosage/adverse effects/classification/therapeutic useAdministration OralPilot ProjectsTissue plasminogen activatorBrain IschemiaCohort Studies2737 Physiology (medical)Atrial Fibrillation80 and overThrombolytic TherapyVitamin K/antagonists & inhibitorsStrokethrombolytic therapyAged 80 and overIncidenceAtrial fibrillationThrombolysisMiddle Aged3. Good healthvitamin K antagonistsTreatment OutcomeAdministrationAcute DiseaseCohortCerebral Hemorrhage/chemically induced/epidemiologyFemaleCardiology and Cardiovascular MedicineAtrial Fibrillation/complicationsmedicine.drugOralmedicine.medical_specialtyanticoagulantsnon-vitamin K antagonist oral anticoagulantsFactor Xa Inhibitors/administration & dosage/adverse effects/therapeutic useintracranial hemorrhagesintra-arterial treatment610 Medicine & healthAntithrombins2705 Cardiology and Cardiovascular MedicineDabigatranFibrinolytic AgentsPhysiology (medical)Internal medicinemedicineischemic strokeHumansAgedCerebral HemorrhageIntracerebral hemorrhageFibrinolytic Agents/therapeutic usebusiness.industryAntithrombins/administration & dosage/adverse effects/therapeutic usemedicine.diseaseddc:616.810040 Clinic for Neurologyanticoagulants; endovascular procedures; intra-arterial treatment; intracranial hemorrhages; ischemic stroke; non-vitamin K antagonist oral anticoagulants; thrombolytic therapy; vitamin K antagonistsPropensity score matchingbusinessFactor Xa InhibitorsCirculation
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Prevalence and Cognitive Impact of Medial Temporal Atrophy in a Hospital Stroke Service: Retrospective Cohort Study

2015

Background Cerebrovascular disease and neurodegeneration cause cognitive impairment and frequently coexist. Aims Our objectives were to investigate the prevalence and cognitive impact of medial temporal lobe atrophy – a radiological marker often associated with Alzheimer's disease – in a hospital stroke service. Methods Retrospective cohort study of patients from a hospital stroke service. Patients assessed for suspected ischemic stroke or transient ischemic attack, irrespective of final diagnosis, underwent neuropsychological testing and magnetic resonance imaging. medial temporal lobe atrophy, white matter hyperintensities, lacunes, and cerebral microbleeds were rated using established cr…

Malemedicine.medical_specialtyPathologyPopulationNeuropsychological TestsSeverity of Illness IndexBrain IschemiaInternal medicinePrevalencemedicineHumansCerebral amyloid angiopathyeducationVascular dementiaStrokeRetrospective Studieseducation.field_of_studymedicine.diagnostic_testbusiness.industryMagnetic resonance imagingRetrospective cohort studyOdds ratioMiddle Agedmedicine.diseaseMagnetic Resonance ImagingTemporal LobeHyperintensityHospitalizationStrokeLogistic ModelsNeurologyMultivariate AnalysisCardiologyFemaleAtrophyVerbal memoryCognition DisordersbusinessMedial temporal lobe atrophyInternational Journal of Stroke
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Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality

2022

[Background and Purpose] Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year.

StrokeVaccine-induced immune thrombotic thrombocytopeniaSDG 3 - Good Health and Well-beingCerebral venous thrombosisSARS-CoV-23112 NeurosciencesCOVID-19COVID-19; Cerebral venous thrombosis; Vaccine-induced immune thrombotic thrombocytopenia; Mortality; SARS-CoV-2; StrokeNeurology (clinical)MortalityCardiology and Cardiovascular Medicine3124 Neurology and psychiatryCOVID-19; Cerebral venous thrombosis; Mortality; SARS-CoV-2; Stroke; Vaccine-induced immune thrombotic thrombocytopeniaJournal of Stroke
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Domain-specific trends in cognitive impairment after acute ischaemic stroke.

2012

Little is known about the pattern of subacute cognitive domain impairments after ischaemic stroke, nor the temporal evolution of such impairments. Our objective was to investigate the pattern of cognitive impairment in different neuropsychological domains up to a year after ischaemic stroke. We included prospectively collected data from an observational database of stroke patients at the National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. Patients were categorised into temporal groups according to the time between the index stroke and neuropsychological profiling. The prevalence of impairment in different cognitive domains was then compared between these categories. …

AdultMalemedicine.medical_specialtyNeurologyTime Factorsmedicine.medical_treatmentNeuropsychological TestsStatistics NonparametricCohort StudiesPhysical medicine and rehabilitationmedicineDementiaHumansNeuroradiologyAgedAged 80 and overischaemic strokeRehabilitationSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicabusiness.industryNeuropsychologyCognitionMiddle Agedmedicine.diseaseStrokeNeurologyCohortPhysical therapyFemaleNeurology (clinical)Verbal memorybusinessCognition DisordersJournal of neurology
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MRI-visible perivascular spaces: relationship to cognition and small vessel disease MRI markers in ischaemic stroke and TIA.

2013

Background MRI-visible perivascular spaces (PVS) are potential neuroimaging markers of cerebral small vessel disease, but their functional significance and mechanisms remain uncertain. We investigated the association between PVS and cognitive impairment, and other MRI markers of small vessel disease, in a patient cohort of ischaemic stroke/transient ischaemic attack (TIA) referrals. Methods Data were collected from a prospective observational database. Standardised detailed neuropsychological testing was performed. A validated visual rating scale on T-2-weighted MRI was used to categorise PVS severity; validated scales were used to assess white matter hyperintensities (WMH), cerebral microb…

Malemedicine.medical_specialtyPathologyLacunar strokeImage AnalysisCohort StudiesNeuroimagingInternal medicineCentrum semiovalemedicineDementiaHumans1506Perivascular spaceStrokeAgedmedicine.diagnostic_testSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicabusiness.industryMagnetic resonance imagingsmall vessel disease cognitionMiddle Agedmedicine.diseaseMagnetic Resonance ImagingHyperintensityStrokePsychiatry and Mental healthmedicine.anatomical_structureIschemic Attack TransientCerebral Small Vessel DiseasesCerebrovascular DiseaseCardiologycardiovascular systemSurgeryFemaleNeurology (clinical)businessCognition DisordersMRI
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Domain-specific characterisation of early cognitive impairment following spontaneous intracerebral haemorrhage.

2018

Cognitive deficits after spontaneous intracerebral haemorrhage (ICH) are common and result in functional impairment, but few studies have examined deficits across cognitive domains in the subacute phase. This study aims to describe the cognitive profile following acute ICH and explore how cerebral amyloid angiopathy (CAA) may impact performance. We retrospectively reviewed 187 consecutive patients with ICH (mean age 58.9 years, 55.6% male) with available imaging and neuropsychological data (median 12 days after stroke). In our cohort, 84% (n = 158) were impaired in at least one cognitive domain and 65% (n = 122) in two or more domains. Deficits in non-verbal IQ (76.6%), information processi…

0301 basic medicineMalemedicine.medical_specialtyVisual perceptionTime FactorsAudiologyNeuropsychological Tests03 medical and health sciences0302 clinical medicineMedicineHumansCognitive Dysfunctioncardiovascular diseasesCognitive impairmentStrokeCerebral HemorrhageRetrospective Studiesbusiness.industryNeuropsychologyBrainCognitionMiddle Agedmedicine.diseaseExecutive functionsMagnetic Resonance Imaging030104 developmental biologyNeurologyCohortFemaleNeurology (clinical)Cerebral amyloid angiopathybusiness030217 neurology & neurosurgeryJournal of the neurological sciences
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