OXIDATIVE STRESS MARKERS ASSOCIATED WITH MIDDLE DISTANCE RUNNING PERFORMANCE

The aim of this study was to understand the mechanism underlying the physiological adaptation of a kind purely aerobic workout. Particular attention has also been given to the analysis of oxidative stress by detecting some enzymatic blood parameters. We investigate the effect of 2 months of training on middle distance running (800 meters and 1500 meters) agonistic athletes; nine active specifically trained males of mean (± SD) age 19,9 years. The physiological characteristics of middle runners are different from those sprinters and long distance runners because include a variety of aerobic and anaerobic capabilities. Two weeks prior to the 2 months period of exercise, subjects were tested f…

Plasma membrane redox system in the erythrocytes of rowers: Pilot study

The oxidative stress results from a change in the physiological balance between oxidant and antioxidant species. This type of stress is a chemical change in the redox state of cells. The increased production of reactive species is related to an excessive metabolic activation, for example, from an intense physical exercise or an excessive caloric intake (1). In physiological conditions, muscle fibers are provided with an antioxidant system able to keep under control the excessive production of Reactive Oxygen Species (ROS).

Bio-Psycho-Social Analysis of the Effect of Superjump Training

PLASMA MEMBRANE REDOX SYSTEM IN THE ERYTHROCYTES OF ROWERS: PILOT STUDY

Background: The oxidative stress results from a change in the physiological balance between oxidant and antioxidant species. The purpose of this study is twofold: first, to investigate the effects of long-term training in sports with high energy requirements on the redox balance which exists between the plasma vs. the erythrocytes; second, to study the activity of the PMRS (Plasma Membrane Redox System), which is a compensatory mechanism of cellular redox homeostasis, in the rowers’ erythrocytes in order to determine the rowers’ counteraction to oxidative stress. Methods: Venous blood samples was collected from rowers and control group; then FRAP (Ferric Reducing Activity Power) method has …

Effect of extracellular vesicles from CSF of multiple sclerosis patients and healthy controls on astrocytes in culture

INTRODUCTION Secretion of extracellular vesicles (EVs) and EV-mediated exchange of molecules among brain cells, under physiological conditions, has been described years ago. At the same time, ability of EVs to transfer proteins and nucleic acids to the surrounding cells, thus modifying their phenotypes, has been clearly demonstrated for tumor cells of different origins, including brain cancers. More recently, involvement of EVs in pathological processes affecting the Central Nervous System (CNS), and their capacity of transferring damaging cargoes have been also suggested. To explore these functions, we exposed primary cultures of astrocytes to EVs isolated from cerebral spinal fluid (CSF) …

Il destino delle catene polipeptidiche dalla sintesi fino alla maturazione: una panoramica

Type 2 diabetes family histories, body composition and fasting glucose levels: A cross-section analysis in healthy sedentary male and female

Background: Diabetes type 2 is a world wide spread disease with a multifactorial pathogenetic evolution. Various factors like obesity, physical inactivity and poor lifestyle habits contribute to its development. The aim of this study was to verify if in young healthy sedentary male and female there is positive correlation between family history to type 2 diabetes and an increase in body weight and fat mass, or alterations in basal glycemia values. Methods: Totally183 male and 237 female healthy sedentary subjects were analysed in 2012, in Italy. They were divided in three groups: FH+ with first degree family history, FH++ with second degree family history and FH− with no family history. Ant…

Carbohydrates consumption pre exercise attenuate bone resorption marker in young female gymnasts

Purpose: Bone mineral density (BMD) is modified by environmental factors like diet, nutritional status and exercise. Athletes have higher bone turnover than sedentary individuals but prolonged exercise might result in a negative remodeling balance and compromise skeletal health. Strenuous exercise and fasting may induce osteoclastic activity that is not necessarily accompanied by a compensatory increase in osteoblastic activity. The purpose of this study was to understand if there is specific nutrition to allow best performance and reduce bone resorption that occurs after exercise in athletes. Methods: A group of 28 gymnasts aged between 9 and 14 years old (13 ± 1.71) playing artistic gymna…

The effects of a 3-week training on basal biomarkers in professional soccer players during the preseason preparation period

Exercise and lactate production:implication in fatigue and in brain signaling

More than two hundred years after its discovery, lactate still remains an intriguing molecule. Considered for a long time as a waste product of metabolism and the culprit behind muscular fatigue, it was then recognized as an important fuel for many cells. In particular, in the nervous system, it has been proposed that lactate, released by astrocytes in response to neuronal activation, is taken up by neurons, oxidized to pyruvate and used for synthesizing acetyl-CoA to be used for the tricarboxylic acid cycle. More recently, in addition to this metabolic role, the discovery of a specific receptor prompted a reconsideration of its role, and lactate is now seen as a sort of hormone, even invol…