0000000001123524

AUTHOR

Kazuhiko Kotani

showing 2 related works from this author

The Effects of Tamoxifen on Plasma Lipoprotein(a) Concentrations: Systematic Review and Meta-Analysis

2017

Introduction: Tamoxifen is a selective estrogen receptor modulator widely used in the treatment of breast cancer. Tamoxifen therapy is associated with reduced circulating low-density lipoprotein cholesterol and increased triglycerides, but its effects on other lipids are less-well studied. Aims: We aimed to investigate the effect of tamoxifen on circulating concentrations of lipoprotein(a) (Lp(a)) through systematic review and meta-analysis of available randomized controlled trials (RCTs) and observational studies. Methods: This study was registered in the PROSPERO database (CRD42016036890). Scopus, Medline and EMBASE were searched from inception until 22nd March 2016 to identify studies in…

OncologySelective Estrogen Receptor Modulatorsmedicine.medical_specialtyRMTamoxifen; lipoprotein(a) concentration; circulation; treatmentBreast Neoplasms030204 cardiovascular system & hematologylaw.invention03 medical and health sciences0302 clinical medicineBreast cancerRandomized controlled triallawInternal medicineCell Line TumormedicineHumansPharmacology (medical)QDRandomized Controlled Trials as Topictreatmentbusiness.industrymedicine.diseaselipoprotein(a) concentrationConfidence intervalTamoxifenEndocrinologyStrictly standardized mean differenceSelective estrogen receptor modulator030220 oncology & carcinogenesisMeta-analysiscirculationFemaleSystematic ReviewbusinessTamoxifenmedicine.drugLipoproteinLipoprotein(a)
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Lipoprotein(a) Levels in Patients With Abdominal Aortic Aneurysm

2016

Circulating markers relevant to the development of abdominal aortic aneurysm (AAA) are currently required. Lipoprotein(a), Lp(a), is considered a candidate marker associated with the presence of AAA. The present meta-analysis aimed to evaluate the association between circulating Lp(a) levels and the presence of AAA. The PubMed-based search was conducted up to April 30, 2015, to identify the studies focusing on Lp(a) levels in patients with AAA and controls. Quantitative data synthesis was performed using a random effects model, with standardized mean difference (SMD) and 95% confidence interval (CI) as summary statistics. Overall, 9 studies were identified. After a combined analysis, patie…

0301 basic medicinemedicine.medical_specialtymacromolecular substances030204 cardiovascular system & hematologyGastroenterology03 medical and health sciences0302 clinical medicineInternal medicineMedicineIn patientcardiovascular diseasesbiologybusiness.industryLipoprotein(a)medicine.diseaseConfidence intervalAbdominal aortic aneurysmSurgery030104 developmental biologyStrictly standardized mean differenceMeta-analysiscardiovascular systembiology.proteinBiomarker (medicine)Cardiology and Cardiovascular MedicinebusinessLipoproteinAngiology
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