0000000001134307
AUTHOR
Julian Druce
Infrared based saliva screening test for COVID‐19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented need for diagnostic testing that is critical in controlling the spread of COVID-19. We propose a portable infrared spectrometer with purpose-built transflection accessory for rapid point-of-care detection of COVID-19 markers in saliva. Initially, purified virion particles were characterized with Raman spectroscopy, synchrotron infrared (IR) and AFM-IR. A data set comprising 171 transflection infrared spectra from 29 subjects testing positive for SARS-CoV-2 by RT-qPCR and 28 testing negative, was modeled using Monte Carlo Double Cross Validation with 50 randomized test and model sets. The testing se…
Dataset and Data analysis for "Infrared based saliva screening test for COVID-19"
External Modelling 1 is the Quasar .ows model to process the Source data 1 to generate the PCA plot shown in Figure 4B and loadings plots in Figure 4C. External Modelling 2 is the MCDCV-PLS-DA Matlab model that can be used in combination with PLS-Tool Box to generate the Receiver Operating Curves (ROC) and the prediction model shown in Figures 4D and 4E, respectively. Source Data 1 is for the PCA modelling. Source Data 2 for the MCDCV-PLS-DA.