0000000001135375

AUTHOR

Raúl Peña

showing 2 related works from this author

How much Is needed? Comparison of the effectiveness of different pain education dosages in patients with fibromyalgia

2019

AbstractObjectiveTo assess the effect of different dosages of pain neuroscience education (PNE) programs on central nociceptive processing in patients with fibromyalgia. Second, to compare the effects of different dosages of PNE programs on numerical pain rating scale (NPRS), disability, and psychological variables.DesignSingle-blind randomized controlled trial.SettingThree fibromyalgia centers in Spain (Valencia, Alcorcón, Alcalá de Henares).SubjectsSeventy-seven patients with fibromyalgia.MethodsParticipants were randomized to four groups of PNE: 1) high-dose PNE (N = 20), 2) low–concentrated dose PNE (N = 20), 3) diluted low-dose PNE (N = 20), and (4) control treatment (N = 17), conducte…

AdultMalePain Thresholdmedicine.medical_specialtyFibromyalgiaTime FactorsDoseAnxietylaw.invention03 medical and health sciences0302 clinical medicinePatient Education as TopicRandomized controlled trial030202 anesthesiologylawFibromyalgiaPressuremedicineHumansSingle-Blind MethodIn patientAgedPain MeasurementControl treatmentbusiness.industryCatastrophizationLarge effect sizeDiffuse noxious inhibitory controlPain PerceptionGeneral MedicineMiddle Agedmedicine.diseasePostsynaptic Potential SummationAnesthesiology and Pain MedicinePhysical therapyFemalePain catastrophizingNeurology (clinical)Human medicinebusiness030217 neurology & neurosurgeryPain medicine
researchProduct

Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer.

2021

[Purpose]: To characterize expression of neuregulin-1 (NRG1), an HER3 ligand, in HER2-positive breast cancer and its relation with the efficacy of trastuzumab with or without pertuzumab.

Cancer ResearchStromal cellReceptor ErbB-2medicine.medical_treatmentNeuregulin-1Drug Evaluation PreclinicalBreast NeoplasmsAntibodies Monoclonal HumanizedBreast cancerAntineoplastic Agents ImmunologicalTrastuzumabAntineoplastic Combined Chemotherapy Protocolsmental disordersmedicineTumor Cells CulturedHumansNeuregulin 1skin and connective tissue diseasesneoplasmsNeoadjuvant therapyRetrospective Studiesbiologybusiness.industryFibroblastsTrastuzumabmedicine.diseasebody regionsTreatment OutcomeOncologyCancer cellbiology.proteinCancer researchImmunohistochemistryFemalePertuzumabbusinessmedicine.drug
researchProduct