Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer.

6533b870fe1ef96bd12cf2aa

RESEARCH PRODUCT

Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer.

Cristina Guardia Ana Rovira Belen Lloveras David Casadevall Luis Soria-jiménez Juan Carlos Montero Oriol Arpí-llucià Pilar Eroles Federico Rojo Barbara Galbardi Joan Albanell Giampaolo Bianchini Joaquín Arribas Raúl Peña Sonia Servitja M. Dugo Luca Gianni Atanasio Pandiella Silvia Menendez Ana Lluch Mohammada Sabbaghi Juan Madoz-gúrpide

subject

Cancer Research Stromal cell Receptor ErbB-2 medicine.medical_treatment Neuregulin-1 Drug Evaluation Preclinical Breast Neoplasms Antibodies Monoclonal Humanized Breast cancer Antineoplastic Agents Immunological Trastuzumab Antineoplastic Combined Chemotherapy Protocols mental disorders medicine Tumor Cells Cultured Humans Neuregulin 1 skin and connective tissue diseases neoplasms Neoadjuvant therapy Retrospective Studies biology business.industry Fibroblasts Trastuzumab medicine.disease body regions Treatment Outcome Oncology Cancer cell biology.protein Cancer research Immunohistochemistry Female Pertuzumab business medicine.drug

description

[Purpose]: To characterize expression of neuregulin-1 (NRG1), an HER3 ligand, in HER2-positive breast cancer and its relation with the efficacy of trastuzumab with or without pertuzumab.

year	journal	country	edition	language
2021-01-01

https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=15900

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