Author: Rocío Falcón

0000000001138860

AUTHOR

Rocío Falcón

showing 2 related works from this author

High vancomycin MICs within the susceptible range in Staphylococcus aureus bacteraemia isolates are associated with increased cell wall thickness and…

2016

Vancomycin minimum inhibitory concentrations (MICs) at the upper end of the susceptible range for Staphylococcus aureus have been associated with poor clinical outcomes of bloodstream infections. We tested the hypothesis that high vancomycin MICs in S. aureus bacteraemia isolates are associated with increased cell wall thickness and suboptimal bacterial internalisation or lysis by human phagocytes. In total, 95 isolates were evaluated. Original vancomycin MICs were determined by Etest. The susceptibility of S. aureus isolates to killing by phagocytes was assessed in a human whole blood assay. Internalisation of bacterial cells by phagocytes was investigated by flow cytometry. Cell wall thic…

0301 basic medicineMicrobiology (medical)Staphylococcus aureusLysisGenotyping Techniques030106 microbiologyBacteremiaMicrobial Sensitivity TestsBiologymedicine.disease_causeStaphylococcal infectionsMicrobiologyFlow cytometry03 medical and health sciences0302 clinical medicineCell WallVancomycinmedicineHumansPharmacology (medical)030212 general & internal medicineMinimum inhibitory concentration (MIC)EtestPhagocytesCell wall thicknessMicrobial Viabilitymedicine.diagnostic_testGeneral MedicineHuman phagocytesStaphylococcal InfectionsFlow CytometryMicroarray Analysismedicine.diseaseEndocytosisAnti-Bacterial AgentsIntracellular killingInfectious DiseasesStaphylococcus aureusBacteremiaVancomycinIntracellularmedicine.drugInternational Journal of Antimicrobial Agents

researchProduct

Intra- and Interinstitutional Evaluation of an Etest for Vancomycin Minimum Inhibitory Concentration Measurement inStaphylococcus aureusBlood Isolate…

2015

Microbiology (medical)Minimum inhibitory concentrationInfectious Diseasesbusiness.industryStaphylococcus aureusmedicineVancomycinbusinessmedicine.disease_causeEtestMicrobiologymedicine.drugMinimum Inhibitory Concentration measurementClinical Infectious Diseases

researchProduct

PEPhysical Sciences and Engineering
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LSLife Sciences
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SHSocial Sciences and Humanities
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