0000000001145731
AUTHOR
T Barnes
Large-scale gene-centric analysis identifies novel variants for coronary artery disease.
Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including analysis of many uncommon and functional variants. We examined 49,094 genetic variants in ∼2,100 genes of cardiovascular relevance, using a customised gene array in 15,596 CAD cases and 34,992 controls (11,202 cases and 30,733 controls of European descent; 4,394 cases and 4,259 controls of South Asian origin). We attempted to replicate putative novel associations in an additional 17,121 CAD cases and 40,473 controls. Potential mechanisms through w…
Physics with Antiprotons at the Future GSI Facility
Recently GSI presented the plans for a major new international research facility (http://www.gsi.de/GSI-future/). Highly luminous secondary beams with excellent quality encompassing the production of antiprotons will be delivered. In a High Energy Storage Ring (HESR) with a bending power of 50 Tm antiprotons will be cooled either stochastically or by electrons. The envisaged limits are a momentum range of 1.5 to 15 GeV/c and a luminosity of 2 × 1032 cm-2 s-1. Four major physical research goals can be addressed: high precision charmonium spectroscopy, medium effects of open and hidden charm, the search for glueballs and hybrids, and the production of hypernuclei.