Modular quintics inℙ4

We will examine the arithmetic of some of the members of a pencil of symmetric quintics in projective 4-space. We will give evidence for the modularity of some of the exceptional members (even the non-rigid ones) and give a proof in one rigid case. (© 2003 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Syphilis 2001 a palaeopathological reappraisal

The origin and subsequent spread of the treponematoses, especially that of venereal syphilis, has been the subject of considerable scientific attention. Various theories were put forth and palaeopathological specimens were used for their validation in recent times. One influential contribution was the paper by Baker & Armelagos in 1988. Numerous new findings and results on both sides of the Atlantic call for a new evaluation of the available osseous material. A review of the recent literature leads to the suggestion of a worldwide distribution of non-venereal treponemal disease since the emergence of Homo and to a first epidemic outbreak of venereal syphilis in Europe of the late 15th and t…

Degenerative alterations of the spine in an Early Mediaeval population from Mannheim-Seckenheim, Germany

Abstract Palaeopathological and palaeoepidemiological analyses of human skeletal remains are some of the most important bases for the reconstruction of life of past populations. The assessment of frequency and degree of pathological alterations contributes to conclusions of a population's health status, labour conditions, and environmental influences. Degenerative diseases of the spine are among the most common lesions observed in archaeological human remains. The large number of excavated Early Mediaeval cemeteries in Germany enables the comparison of contemporary populations increasing the reliability of conclusions regarding their living conditions. In this study, 112 adult individuals w…

Social differentiation and land use at an Early Iron Age “princely seat”: bioarchaeological investigations at the Glauberg (Germany)

Excavations at the late Hallstatt/early La Tene (6th–4th century BC) “princely seat” of the Glauberg (Hesse, Germany) revealed exceptionally furnished graves in monumental mounds, simple inhumations in associated ditches and non-normative burials of up to eight individuals in conical storage pits. The study presented here addresses bioarchaeological characteristics of these burials and their implications for social differentiation and the sphere of influence of the “princely seat”. It includes osteological, aDNA, and multi-isotope analyses of 27 human individuals and faunal remains. One of the outstandingly rich graves (tumulus 1/grave 1) contained the skeleton of a young man (the “prince”)…

Modular Calabi-Yau threefolds of level eight

In the studies on the modularity conjecture for rigid Calabi-Yau threefolds several examples with the unique level 8 cusp form were constructed. According to the Tate Conjecture correspondences inducing isomorphisms on the middle cohomologies should exist between these varieties. In the paper we construct several examples of such correspondences. In the constructions elliptic fibrations play a crucial role. In fact we show that all but three examples are in some sense built upon two modular curves from the Beauville list.

Stepwise Approach to Atrial Fibrillation Mapping and Ablation in Persistent and Long-standing Persistent Atrial Fibrillation

Ancient DNA, Strontium isotopes, and osteological analyses shed light on social and kinship organization of the Later Stone Age.

In 2005 four outstanding multiple burials were discovered near Eulau, Germany. The 4,600-year-old graves contained groups of adults and children buried facing each other. Skeletal and artifactual evidence and the simultaneous interment of the individuals suggest the supposed families fell victim to a violent event. In a multidisciplinary approach, archaeological, anthropological, geochemical (radiogenic isotopes), and molecular genetic (ancient DNA) methods were applied to these unique burials. Using autosomal, mitochondrial, and Y-chromosomal markers, we identified genetic kinship among the individuals. A direct child-parent relationship was detected in one burial, providing the oldest mol…

Osteological evidence for the Battles of Zürich, 1799: a glimpse into soldiery of the past

Institute of Anthropology, University of Mainz, GermanyABSTRACT Four human skeletons probably could be attributed to people killed during the Battles ofZu¨rich in 1799. Cranial and postcranial gunshot wounds are consistent with those made byblack powder weapons using lead balls as ammunition. Additional finds include a probablecase of Scheuermann’s Disease and a pipe smoker’s facet. Copyright 2003 John Wiley S Switzerland; gunshot wounds; Scheuermann’s disease; pipesmoking; palaeopathology

The Eulau eulogy: Bioarchaeological interpretation of lethal violence in Corded Ware multiple burials from Saxony-Anhalt, Germany

The Corded Ware is one of the major archaeological traditions of Late Neolithic Europe. Its burial customs are characterized by single graves but multiple burials also occur. We present a detailed study of antemortem and perimortem trauma in a group of Corded Ware skeletons from four multiple graves and give the most probable interpretation of the site, based upon all available bioarchaeological evidence. The pattern of observed injuries in male, female, and subadult skeletons, including cranial trauma, arrow wounds, and fractures of the forearm and hands points towards a violent event that resulted in the death of all individuals, most probably a raid. In contrast to comparable Neolithic r…

Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial

PURPOSE Antitumor activity in preclinical models and a phase I study of patients with dedifferentiated liposarcoma (DD-LPS) was observed with selinexor. We evaluated the clinical benefit of selinexor in patients with previously treated DD-LPS whose sarcoma progressed on approved agents. METHODS SEAL was a phase II-III, multicenter, randomized, double-blind, placebo-controlled study. Patients age 12 years or older with advanced DD-LPS who had received two-five lines of therapy were randomly assigned (2:1) to selinexor (60 mg) or placebo twice weekly in 6-week cycles (crossover permitted). The primary end point was progression-free survival (PFS). Patients who received at least one dose of st…

Autophagy

Klionsky, Daniel J. et al.

Late Jurassic globetrotters compared: A closer look at large and giant theropod tracks of North Africa and Europe

Abstract Late Jurassic theropod tracks are very common both in North Africa and Europe. Two recently described ichnotaxa Megalosauripus transjuranicus and Jurabrontes curtedulensis from the Kimmeridgian of Switzerland show the coexistence of two apex predators in the same palaeoenvironment. Similar tracks can be found in tracksites from the Iberian Peninsula and from Morocco. Here, we further explore the similarities among the Swiss ichnotaxa and the other tracks from Germany (Kimmeridgian), Spain (Tithonian-Berriasian), Portugal (Oxfordian-Tithonian) and Morocco (Kimmeridgian) through novel three-dimensional data comparisons. Specimens were grouped in two morphotypes: 1) large and gracile …

The massacre mass grave of Schöneck-Kilianstädten reveals new insights into collective violence in Early Neolithic Central Europe

Conflict and warfare are central but also disputed themes in discussions about the European Neolithic. Although a few recent population studies provide broad overviews, only a very limited number of currently known key sites provide precise insights into moments of extreme and mass violence and their impact on Neolithic societies. The massacre sites of Talheim, Germany, and Asparn/Schletz, Austria, have long been the focal points around which hypotheses concerning a final lethal crisis of the first Central European farmers of the Early Neolithic Linearbandkeramik Culture (LBK) have concentrated. With the recently examined LBK mass grave site of Schöneck-Kilianstädten, Germany, we present ne…

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Contains fulltext : 232759.pdf (Publisher’s version ) (Closed access) In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to…

Autophagy

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide…

Tracing patterns of activity in the human skeleton: an overview of methods, problems, and limits of interpretation.

Studies of patterns of activity in human skeletal remains have grown in number over the last few years. Different methods have been used to reconstruct activity patterns in past populations. In this review of the available literature the common themes of these studies have been isolated in order to show that many studies do not truly conform to the standards of the field. Inadequate sample size, too far-reaching conclusions and neglect of other possible explanations are among the problems easily recognised in the literature. Many assumptions are lacking a sound experimental basis, and it becomes increasingly evident that there are many more problems and limits of interpretations than have b…