A Model for the Description, Simulation, and Deconvolution of Skewed Chromatographic Peaks

A family of models is proposed for the description of skewed chromatographic peaks, based on the modification of the standard deviation of a pure Gaussian peak, by the use of a polynomial function, h(t) = He-(1/2)([t-tR]/[s0+s1(t-tR)+s2(t-tR)2+...])2, where H and tR are the height and time at the peak maximum, respectively. The model has demonstrated a high flexibility with peaks of a wide range of asymmetry and can be used to accurately predict the profile of asymmetrical peaks, using the values of efficiency and asymmetry factor measured on experimental chromatograms. This possibility permits the simulation of chromatograms and the optimization of the separation of mixtures of compounds p…