0000000001159711

AUTHOR

Albert Vaca

showing 2 related works from this author

Designed Synthesis of New ortho-Carborane Derivatives: from Mono- to Polysubstituted Frameworks

2008

The use of nucleophilic and electrophilic processes allow the designed synthesis of several B-iodinated derivatives of o-carborane. Because of the straightforward Pd-catalyzed conversion of B-I to B-C bond with Grignard reagents, such as methylMgBr and biPhenylMgBr, both, symmetrical 3,6-R 2-1,2- closo-C 2B 10H 10 and asymmetrical 3-I-6-Me-1,2- closo-C 2B 10H 10 could be obtained. Not only conventional reactions in solution have been studied but also a highly efficient, clean and fast solvent-free procedure has provided successful results to regioselectively produce B-iodinated o-carborane derivatives by a careful control of the reaction conditions. The high number of nonequivalent leaving …

ChemistryHalogenationchemistry.chemical_elementCrystal structureCombinatorial chemistryInorganic ChemistryNucleophilePolarizabilityReagentElectrophileOrganic chemistryCarboranePhysical and Theoretical ChemistryBoronInorganic Chemistry
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A solvent-free regioselective iodination route of ortho-carboranes.

2006

Tetraiodo-ortho-carborane based X-ray contrast agents can be readily prepared in a high yield, fast, clean, regioselective fashion by a solvent-free reaction of ortho-carboranes with iodine in sealed tubes.

inorganic chemicalsBoron Compoundschemistry.chemical_elementContrast MediaOrganic-reactions010402 general chemistryIodine01 natural sciencesChemical synthesisInorganic ChemistryQUIMICA ANALITICAOrganic chemistryheterocyclic compoundsSolvent freeintegumentary system010405 organic chemistryChemistryorganic chemicalsRegioselectivityHalogenationCombinatorial chemistry0104 chemical sciencesRadiographyChemical-synthesisOrganic reactionYield (chemistry)SolventsbacteriaDerivativesIodineDalton transactions (Cambridge, England : 2003)
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