0000000001164671

AUTHOR

A. Anfosso

showing 1 related works from this author

Skewed Differentiation of Circulating Vγ9Vδ2 T Lymphocytes in Melanoma and Impact on Clinical Outcome

2016

OBJECTIVE:The aim of this study was to evaluate over time circulating γδ T lymphocytes in melanoma patients in terms of frequency, effector functions, and relationship with clinical stage and evolution, by comparing preoperative values to those obtained at a mean follow-up of 36 months or in the event of recurrence or disease progression, and to those of healthy controls. Also, we correlated the presence of tumor-infiltrating γδ T lymphocytes with clinical evolution of melanoma. RESULTS:Mean frequencies of circulating γδ T cells before and after melanoma removal were very similar and comparable to healthy subjects, but patients who progressed to stage III or IV showed a significantly decrea…

MelanomasMale0301 basic medicineSkin NeoplasmsCellular differentiationmedicine.medical_treatmentSettore MED/19 - Chirurgia Plasticalcsh:MedicineWhite Blood Cells0302 clinical medicineAnimal CellsMedicine and Health SciencesMedicineCytotoxic T cellStage (cooking)lcsh:ScienceMelanomaγδ T lymphocytes melanoma prognostic biomarkerCultured Tumor CellsAged 80 and overMultidisciplinaryT CellsEffectorMelanomaCell DifferentiationReceptors Antigen T-Cell gamma-deltaMiddle AgedPrognosisPhenotypeSurgical OncologyPhenotypeCytokineOncology030220 oncology & carcinogenesisCutaneous MelanomaMelanoma CellsFemaleImmunotherapyBiological CulturesCellular TypesResearch ArticleAdultDeath RatesImmune CellsImmunologyMalignant Skin NeoplasmsSurgical and Invasive Medical ProceduresDermatologyResearch and Analysis Methods03 medical and health sciencesLymphocytes Tumor-InfiltratingPopulation MetricsHumansDemographyAgedNeoplasm StagingSettore MED/04 - Patologia GeneraleBlood CellsPopulation Biologybusiness.industrylcsh:RCase-control studyBiology and Life SciencesCancers and NeoplasmsCell BiologyCell Culturesmedicine.disease030104 developmental biologyCase-Control StudiesPeople and PlacesImmunologylcsh:QClinical ImmunologyClinical MedicinebusinessPLOS ONE
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