Toxicity test of a dental commercial composite in rats.

Objective: The aim of this study was to determine the 90-day subchronic toxicity of one triethylene glycol dimethacrylate containing composite (MEDENTAL Light-Cure Composite™) orally administered to rats according to OECD no. 48 guidelines and the requirements specified in the International Organization for Standardization 10993-11. Study design: The composite was administered orally to Wistar rats during 90 days and they were observed to determine changes in their behavior, eye and skin signs and other attitudes such as aggressiveness, posture, walking and response to handling. After 90 days they were sacrificed to determine blood alterations, special hematological tests were done and hist…