0000000001165804

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Environment Susceptibility-reykjavik Study Investigators

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Persistence of the effect of birth size on dysglycaemia and type 2 diabetes in old age: AGES-Reykjavik Study

2012

We studied the effect of birth size on glucose and insulin metabolism among old non-diabetic individuals. We also explored the combined effect of birth size and midlife body mass index (BMI) on type 2 diabetes in old age. Our study comprised 1,682 Icelanders whose birth records included anthropometrical data. The same individuals had participated in the prospective population-based Reykjavik Study, where BMI was assessed at a mean age of 47 years, and in the AGES-Reykjavik Study during 2002 to 2006, where fasting glucose, insulin and HbA₁c were measured and homeostasis model assessment for the degree of insulin resistance (HOMA-IR) calculated at a mean age of 75.5 years. Type 2 diabetes was…

Blood GlucoseMaleAgingmedicine.medical_specialtyPediatricsBirth weightPopulationIcelandType 2 diabetesWeight GainArticleBody Mass IndexInsulin resistanceDiabetes mellitusInternal medicinemedicineBirth WeightHumansInsulinsyntymäpainoProspective StudieseducationAgedAged 80 and overGlucose tolerance testeducation.field_of_studydiabetesmedicine.diagnostic_testbusiness.industryIncidenceagingGeneral MedicineGlucose Tolerance TestMiddle Agedmedicine.diseaseLow birth weightikääntyminenEndocrinologyDiabetes Mellitus Type 2Population SurveillanceDisease ProgressionFemaleInsulin ResistanceGeriatrics and Gerontologymedicine.symptombusinessBody mass indexbirth sizeFollow-Up StudiesAGE
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