Applications of mathematical modelling to the simulation of binary perfusion chromatography

Abstract A mathematical model of binary (competitive adsorption involving two components) perfusion chromatography is used to simulate and study the behavior of a binary adsorption system. The dynamic behavior of column systems (frontal analysis) is examined for different particles sizes, column fluid superficial velocities, Vf, and intraparticle fluid velocities, νp. Column systems with perfusive (νp > 0) and purely diffusive (νp = 0) adsorbent particles are studied. The results obtained from the binary system studied in this work suggest that the times at which breakthrough begins for components 1 and 2, and the dynamic (unsteady state) relative separation between components 1 and 2 obtai…