0000000001179935

AUTHOR

Giuseppe Girbino

showing 6 related works from this author

Disability in moderate chronic obstructive pulmonary disease: Prevalence, burden and assessment-results from a real-life study

2014

<b><i>Background:</i></b> The role of disability and its association with patient-reported outcomes in the nonsevere forms of chronic obstructive pulmonary disease (COPD) has never been explored. <b><i>Objectives:</i></b> The aim of this study was to assess, in a cross-sectional real-life study, the prevalence and degree of disability in moderate COPD patients and to assess its association with health status, illness perception, risk of death and well-being. <b><i>Methods:</i></b> Moderate COPD outpatients attending scheduled visits were involved in a quantitative research program using a questionnaire-based data collec…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtyChronic ObstructiveActivities of daily livingCross-sectional studyHealth StatusPulmonary diseaseChronic obstructive pulmonary disease; Disability; Patient-reported outcomes; Activities of Daily Living; Aged; Cross-Sectional Studies; Disability Evaluation; Female; Health Status; Humans; Italy; Male; Middle Aged; Pulmonary Disease Chronic Obstructive; Pulmonary and Respiratory MedicineSettore MED/10 - Malattie Dell'Apparato RespiratorioChronic obstructive pulmonary disease; Disability; Patient-reported outcomes; Activities of Daily Living; Aged; Cross-Sectional Studies; Disability Evaluation; Female; Health Status; Humans; Italy; Male; Middle Aged; Pulmonary Disease Chronic Obstructive; Pulmonary and Respiratory Medicine; Medicine (all)Illness perceptionsPulmonary DiseasePulmonary Disease Chronic ObstructiveDisability EvaluationActivities of Daily LivingMedicineHumansDisease burdenAgedCOPDDisabilityPatient-reported outcomesbusiness.industryMedicine (all)Chronic obstructive pulmonary diseaseMiddle Agedmedicine.diseaseCross-Sectional StudiesItalyPhysical therapyFemaleRisk of deathbusinessLife study
researchProduct

Asthma management in a specialist setting: Results of an Italian Respiratory Society survey.

2017

Abstract Background Asthma considerably impairs patients' quality of life and increases healthcare costs. Severity, morbidity, and degree of disease control are the major drivers of its clinical and economic impact. National scientific societies are required to monitor the application of international guidelines and to adopt strategies to improve disease control and better allocate resources. Aim to provide a detailed picture of the characteristics of asthma patients and modalities of asthma management by specialists in Italy and to develop recommendations for the daily management of asthma in a specialist setting. Method: A quantitative research program was implemented. Data were collected…

Pulmonary and Respiratory MedicineAdultMalemedicine.medical_specialtyConcordanceSocio-culturalePractice PatternsSettore MED/10 - Malattie Dell'Apparato RespiratorioSeverity of Illness Index03 medical and health sciences0302 clinical medicineQuality of life (healthcare)Retrospective StudieSurveys and QuestionnairesSeverity of illnessHealth caremedicineSurveys and QuestionnaireHumansPharmacology (medical)030212 general & internal medicinePractice Patterns Physicians'Adult; Aged; Asthma; Female; Humans; Italy; Male; Middle Aged; Practice Patterns Physicians'; Retrospective Studies; Severity of Illness Index; Surveys and Questionnaires; Quality of Life; SpecializationAsthmaAgedRetrospective StudiesModalitiesPhysicians'business.industryBiochemistry (medical)Retrospective cohort studyMiddle Agedmedicine.diseaseAsthmaPulmonary and Respiratory Medicine; Biochemistry (medical); Pharmacology (medical)030228 respiratory systemItalyTest scoreFamily medicinePhysical therapyQuality of LifeFemalebusinessHumanSpecializationPulmonary pharmacologytherapeutics
researchProduct

<p>Early management of COPD: where are we now and where do we go from here? A Delphi consensus project</p>

2019

Purpose There is a lack of consensus on the most appropriate early diagnostic strategy, criteria for early access to treatment and follow-up approach for patients with COPD. Materials and methods A Delphi consensus project investigated the early management of COPD. We formulated two questionnaires for completion by pneumologists in Italy. Results A total of 207 specialists completed questionnaire 1 and 184 of them questionnaire 2, between November 2016 and October 2017. Early diagnosis of COPD was considered uncommon for 93.2% of the expert panel. Regardless of the definition of "early diagnosis" - a diagnosis made before the clinical manifestation of the disease for most responders (60.4%)…

COPDmedicine.medical_specialtybiologybusiness.industrymedicine.medical_treatmentDelphi methodGeneral MedicineDiseaseEvidence-based medicineLamamedicine.diseasebiology.organism_classificationNatural history03 medical and health sciences0302 clinical medicine030228 respiratory systemmedicineSmoking cessation030212 general & internal medicineIntensive care medicinebusinessHealth policyInternational Journal of Chronic Obstructive Pulmonary Disease
researchProduct

Quality standards for the management of bronchiectasis in Italy: A national audit

2016

Although historically considered a neglected disease, bronchiectasis has become a disease of renewed interest over recent decades in light of an increase in prevalence and a substantial burden on healthcare systems. In 2010, the British Thoracic Society (BTS) published guidelines on the management of bronchiectasis in adults, along with specific quality standards. To date, these represent the only quality standards available in Europe. These have been tested over a number of years in the UK with progressive improvements in the standard of care. No national guidelines are available in Italy and no indications on which guideline should be followed have been given by the Italian Society of Res…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtybronchiectasismedia_common.quotation_subjectSymptom Flare UpMedical auditSettore MED/10 - Malattie Dell'Apparato Respiratorio03 medical and health sciences0302 clinical medicinemedicinePrevalenceHumansQuality (business)Pseudomonas Infections030212 general & internal medicineIntensive care medicineNational auditmedia_commonAgedMedical AuditBronchiectasisbusiness.industryMedicine (all)Middle Agedmedicine.diseaseSymptom Flare UpAnti-Bacterial AgentsPatient Care Management030228 respiratory systemItalyNeeds assessmentPseudomonas aeruginosaFemalebusinessMedicine (all); Pulmonary and Respiratory MedicineNeeds Assessment
researchProduct

RhinAsthma patient perspective: a short daily asthma and rhinitis QoL assessment.

2012

Background The present study aimed to develop a short validated patient-completed questionnaire, the RhinAsthma Patient Perspective (RAPP), to assess the health-related quality of life (HRQoL) in patients with asthma and comorbid allergic rhinitis in clinical practice. Methods A provisional RAPP questionnaire was formed from candidate items identified through retrospective analysis of 333 RHINASTHMA questionnaires. This was then tested on 150 asthma patients with allergic rhinitis. Results Psychometric analyses identified eight items fitting a unidimensional model to form RAPP. Internal consistency (Cronbach's alpha coefficient > 0.8) and agreement with RHINASTHMA (r = −0.31, P = 0.0001) we…

AdultMalemedicine.medical_specialtyRhinitis Allergic PerennialPsychometricsAdolescentPsychometricsVisual analogue scaleassessmentConcordanceImmunologyPopulationSettore MED/10 - Malattie Dell'Apparato RespiratoriorhinitisAllergicCronbach's alphaQuality of lifeSurveys and Questionnaires80 and overmedicineSurveys and QuestionnaireImmunology and AllergyHumansdaily practiceeducationAsthmaAgedAged 80 and overeducation.field_of_studybusiness.industryassessment; asthma; daily practice; quality of life; rhinitis; Adolescent; Adult; Aged; Aged 80 and over; Asthma; Female; Humans; Male; Middle Aged; Psychometrics; Rhinitis Allergic; Rhinitis Allergic Perennial; Quality of Life; Surveys and Questionnaires; Immunology and Allergy; ImmunologyMiddle Agedmedicine.diseasePerennialRhinitis AllergichumanitiesAsthmarhinitiConvergent validityassessment; asthma; daily practice; quality of life; rhinitisPhysical therapyQuality of LifeFemalebusinessPsychometricHumanAllergy
researchProduct

TGF-β Signaling Pathways in Different Compartments of the Lower Airways of Patients With Stable COPD

2017

Background: The expression and localization of transforming growth factor-β (TGF-β) pathway proteins in different compartments of the lower airways of patients with stable COPD is unclear. We aimed to determine TGF-β pathway protein expression in patients with stable COPD. Methods: The expression and localization of TGF-β pathway components was measured in the bronchial mucosa and peripheral lungs of patients with stable COPD (n = 44), control smokers with normal lung function (n = 24), and control nonsmoking subjects (n = 11) using immunohistochemical analysis. Results: TGF-β1, TGF-β3, and connective tissue growth factor expression were significantly decreased in the bronchiolar epithelium…

MaleCCN2 connective tissue growth factorSmad Proteinsairway inflammationCritical Care and Intensive Care MedicineTRAP-1 transforming growth factor-β receptor-associated binding proteinPulmonary Disease Chronic ObstructiveLAP latency-associated peptideSMAD small mother against decapentaplegicBAMBI CTGF SMAD TGF-B airway inflammation autoimmunityLungTGF transforming growth factorLLC large latent complexBAMBI CTGF SMAD TGF-β Airway Inflammation AutoimmunityautoimmunityMiddle Agedrespiratory systemLTBP latent transforming growth factor-β binding proteinImmunohistochemistryTGIF 5′-TG-3′-interacting factorECM extracellular matrixTGFBI transforming growth factor-β-induced proteinFemaleCardiology and Cardiovascular MedicinePI3K phosphoinositide 3-kinaseSignal TransductionTGF-βPulmonary and Respiratory MedicineTGF-βR TGF-β receptorSocio-culturaleBronchiRespiratory MucosaArticleTGF-BTransforming Growth Factor beta1Transforming Growth Factor beta3Macrophages AlveolarHumansAgedBAMBI; CTGF; SMAD; TGF-β; airway inflammation; autoimmunityBAMBIMembrane ProteinsCTGFBMP bone morphogenetic proteinBAMBI; CTG; SMAD; TGF-β; airway inflammation; autoimmunityCTGBAMBI bone morphogenetic proteins and activin membrane-bound inhibitorrespiratory tract diseasesairway inflammation; autoimmunity; BAMBI; CTGF; SMAD; TGF-β; Pulmonary and Respiratory Medicine; Critical Care and Intensive Care Medicine; Cardiology and Cardiovascular MedicineCase-Control StudiesBiomarkersMAPK mitogen-activated protein kinaseSMAD
researchProduct