PROBLEMS OF DIFFERENTIAL DIAGNOSIS IN PALEOPATHOLOGY

This work discusses on the problems of the differential diagnosis in paleopathology, describing one case of intense modification observed in a skeletal sample from the archaelogical site of Baucina (Sicily, VI century BCE). Difficulties in this setting originate mainly from the aspecificity or absence of pathological markers on ancient bones and confounding features arising from clinical phenocopies or taphonomic artifacts. On the base of an in-depth morphological analysis of the find, with aid of CT scan imaging and wide revision of the medical and paleopathological literature, we arrived to a convincing diagnosis.

Current epidemiological trends and outcome in a large cohort of acute hepatitis C patients.

Twelve Variants Polygenic Score for Low-Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations

: Background A significant proportion of individuals clinically diagnosed with familial hypercholesterolemia (FH), but without any disease-causing mutation, are likely to have polygenic hypercholesterolemia. We evaluated the distribution of a polygenic risk score, consisting of 12 low-density lipoprotein cholesterol (LDL-C)-raising variants (polygenic LDL-C risk score), in subjects with a clinical diagnosis of FH. Methods and Results Within the Lipid Transport Disorders Italian Genetic Network (LIPIGEN) study, 875 patients who were FH-mutation positive (women, 54.75%; mean age, 42.47±15.00 years) and 644 patients who were FH-mutation negative (women, 54.21%; mean age, 49.73±13.54 years) wer…