Water-borne e-beam crosslinked nanogels as nanomaterials platform for drug delivery

Degalatosylated xyloglucan hydrogels: influence of irradiation conditions on physico-chemical properties and structure

Influence of exogenous and endogenous ions on the properties of BSA

E-Beam Crosslinked Polymeric and Bio-Hybrid Nanocarriers for Drug Delivery and Bioimaging

POLYSACCHARIDE-BASED HYDROGELS FOR MYOCARDIUM REMODELING

Large-scale Radiation Manufacturing of Hierarchically Assembled Nanogels

Nanogels (NGs), or small particles formed by physically or chemically crosslinked polymer networks, represent a niche in the development of “smart” nanoparticles for drug delivery and diagnostics. They offer unique advantages over other systems, including a large and flexible surface for multivalent bio-conjugation; an internal 3D aqueous environment for incorporation and protection of (bio)molecular drugs; the possibility to entrap active metal or mineral cores for imaging or phototherapeutic purposes; stimuli-responsiveness to achieve temporal and/or site control of the release function and biocompatibility. The availability of inexpensive and robust preparation methodologies is at the ba…

Effect of Total Apple Polyphenols Extract as Inhibitors of Amyloid Protein Aggregation

Effect of Total Apple Polyphenols Extract as Inhibitors of Amyloid Protein Aggregation By: Guarrasi, Valeria; Rappa, Cinzia Giacoma; Costa, Maria Assunta; et al. JOURNAL OF CLINICAL GASTROENTEROLOGY Volume: 52 Supplement: 1 Pages: S94-S94 Published: NOV-DEC 2018

TEMPERATURE-TRIGGERED MACROSCOPIC GELATION OF IRRADIATED XYLOGLUCANS FOR BIOMEDICAL APPLICATIONS

Discrimination of three Citrus paradisi Macf. cultivars by Electronic Nose Discrimination of three Citrus paradisi Macf. cultivars by Electronic Nose.

Naïve Hsp60, similarly to GroEL, oligomerizes to build heptameric and tetradecameric structures.

Discrimination of hand fresh squeezed and commercial grapefruit juices by electronic nose.

Studies of network structure and dynamics of e-beam crosslinked PVPs: From macro to nano

Much interest has been paid to develop a variety of radiation-crosslinked hydrated polymeric materials, which swell in water but do not dissolve, as biocompatible materials used for wound healing, drug delivery system, surface-coating material for medically used devices, etc. With the aim of establishing design rules to produce hydrogels of controlled size at the nanoscale and desired internal network structure using conventional electron accelerators and set-ups, here we attempt a description in terms of structural and dynamic properties of polymer networks generated through e-beam irradiation of aqueous solutions of the same model polymer, a commercial grade poly(N-vinyl-pyrrolidone), sub…

Entrapment of Aβ(1-40) peptide in unstructured aggregates

Recognizing the complexity of the fibrillogenesis process provides a solid ground for the development of therapeutic strategies aimed at preventing or inhibiting protein-protein aggregation. Under this perspective, it is meaningful to identify the possible aggregation pathways and their relative products. We found that Aβ-peptide dissolved in a pH 7.4 solution at small peptide concentration and low ionic strength forms globular aggregates without typical amyloid β-conformation. ThT binding kinetics was used to monitor aggregate formation. Circular dichroism spectroscopy, AFM imaging, static and dynamic light scattering were used for structural and morphological characterization of the aggre…