Unexpected metal-free synthesis of trifluoromethyl arenes via tandem coupling of dicyanoalkenes and conjugated fluorinated sulfinyl imines
A novel strategy for the synthesis of policyclic trifluoromethyl arenes has been devised. It involves a DBU-promoted tandem cycloaromatization reaction of dicyanoalkenes and fluorinated conjugated sulfinyl imines. This unprecedented transformation is a metal-free and air-tolerant process that takes place from readily available starting materials under mild reaction conditions.
CCDC 1989940: Experimental Crystal Structure Determination
Related Article: Alvaro Sanz-Vidal, Daniel Gaviña, Lia Sotorríos, Enrique Gómez-Bengoa, Fernando López Ortiz, María Sánchez-Roselló, Carlos del Pozo|2021|Chem.Commun.|57|8023|doi:10.1039/D1CC03161A
CCDC 1989936: Experimental Crystal Structure Determination
Related Article: Alvaro Sanz-Vidal, Daniel Gaviña, Lia Sotorríos, Enrique Gómez-Bengoa, Fernando López Ortiz, María Sánchez-Roselló, Carlos del Pozo|2021|Chem.Commun.|57|8023|doi:10.1039/D1CC03161A