Th2 cytokines induce chemotherapy resistance in epithelial tumors via PI3K/AKT pathway

Several studies designate apoptosis as the predominant mechanism by which cancer cells die in response to chemotherapeutic drugs. Moreover, it was suggested that anti-apoptotic molecules activation play a pivotal role in the chemotherapeutic drugs resistance. We have recently demonstrated that the presence of Th2 cytokines in thyroid cancer microenvironment increase FLIP, Bcl-2 and Bcl-xl expression levels and protect cancer cells from chemotherapeutic drugs induced apoptosis. Particularly, in this study we demonstrate that IL-4 and IL-10 promote proliferation and chemotherapy resistance activating the PI3K/AKT signal pathway. Therefore, we extensively studied cell survival-related substrat…

Optimisation of cancer therapy by sensitization of cancer stem cells within tumorsto death indicing regimens

CANCER STEM CELLS CONTRIBUTE TO THE AGGRESSIVE BEHAVIOUR OF HUMAN EPITHELIAL COLON CANCER.

Autocrine production of IL-4 confers resistance to chemotherapy and CD-95 induced cell death in cancer cells.