0000000001192309
AUTHOR
D Noto
Diabetes, family history and extension of coronary atherosclerosis are strong predictors of adverse events after PTCA: a one year follow-up study
Identification of a novel ANGPTL3 mutation splicing associeted to severe hypobetalipoproteinemia
Introduction. Primary hypobetalipoproteinemia (pHBL) is a monogenic heterogeneous condition inherited as a dominant or recessive trait characterized by total cholesterol (TC) and/or LDL cholesterol (LDL-C) and/or apolipoprotein B (APOB) levels below the 5th percentile of the reference population. Heterozygous APOB gene mutations are responsible for the majority of the dominant pHBL causing the familial hypobetalipoproteinemia (FHBL). Loss-of-function mutations in the PCSK9 gene also cause FHBL. Familial combined hypolipidemia is a recently discovered dyslipidemic phenotype characterized by low levels of TC, triglycerides (TG), LDL-C, and high-density lipoprotein cholesterol (HDL-C). The gen…
COMPOUND HETEROZYGOUS FH AND FDB: IDENTIFICATION OF A SICILIAN FAMILY HARBOURING THE FDB3531 MUTATION AND THE Y398X MUTATION OF THE LDL RECEPTOR GENE.
A NOVEL COMPOUND HETEROZYGOUS MUTATION OF THE LIPOPROTEIN LIPASE GENE IN A NEWBORN WITH CHYLOMICRONEMIA
Saturated and unsaturated free fatty acids (FFA) modulate differently HDL uptake in hepatoma HEPG2 cells
Lipoprotein remnants accumulation in end-stage renal disease: evidence of an active role of heparin administration during hemodialysis
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
Background: hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods: we used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prev…
Coronarografia diagnostica e conseguenti scelte terapeutiche dopo l’avvento degli stent alla rapamicina: approccio attuale ed evoluzione degli ultimi dieci anni.
Variations in plasma lipids and in the LDL peak particle size after acute myocardial infarction
A novel mutation in the Lipase Maturaction Factor 1 (LMF-1)gene responsible for severe hypertriglyceridemia
Livelli ridotti di cistatina C nell’infarto miocardico acuto vs. angina instabile, aneurisma aortico e controlli normali
Clinical predictors of adverse events in a 1 year follow-up study post-PCI
Chilomicronemia transitoria causa di diabete di tipo I in assenza di markers umorali di autoimmunità in una bambina di nove anni
Il polimorfismo genico CD14 C(-260)>T non e’ un fattore di rischio per infarto miocardico acuto
Treatment of primary hypercholesterolemia: comparison of the effectiveness of different statins
VARIABLE PHENOTYPIC ESPRESSION IN A LIPID ABSORPTION DISORDER DUE TO A MOLECULAR DEFECT IN THE SARA2 GENE
Diabetes, family history and extension of coronary atherosclerosis are strong predictors of adverse events post-PTCA: a 1 year follow-up study
Prevalenza di fattori di rischio e variazione temporale dei parametri lipidici in una serie consecutiva di 350 infarti acuti del miocardio registrati in una unita’ intensiva di Palermo.
Effects of dialysis on the cardiovascular risk of uremic patients: increase in levels of remnant particles
CLINICAL AND MOLECULAR CHARACTERIZATION OF HYPERCHOLESTEROLEMIC SICILIAN FAMILIES AND DESCRIPTION OF 3 NOVEL MUTATIONS IN THE LDLR GENE
Prothrombotic gene variants in AMI young women
INTERACTION OF THE INTRACELLULAR DOMAIN OF THE LOW DENSITY LIPOPROTEIN (LDL) RECPTOR WITH METALLOTHIONEIN2 (MT2).
La simvastatina riduce le lipoproteine aterogene in pazienti con coronaropatia prematura: effetti delle statine “beyond-cholesterol”
SEVERE MALABSORPTION AND DECREASED TRIGLYCERIDE RICH LIPOPROTEINS PRODUCTION IN A PROBAND CARRYING A MUTATION ENCODING FOR A TRUNCATED APOLIPOPROTEIN B100 VARIANT (APO B 34.8).
Risultati del follow-up di 6 mesi in 100 pazienti con stent medicato con rapamicina rispetto ad altri 100 con stent tradizionale
Changes in levels of triglyceride-rich lipoprotein subfractions during dialysis in uremic patients
CD14 C(-260)>T gene polymorphism is not a risk factor for myocardial infarction
A NOVEL APOB MUTATION IDENTIFIED BY EXOME SEQUENCING COSEGREGATES WITH STEATOSIS, LIVER CANCER AND HYPOCHOLESTEROLEMIA
Objective. In familial hypobetalipoproteinemia (FHBL), fatty liver is a characteristic feature, and there are several reports of associated cirrhosis and hepatocarcinoma. We investigated a large kindred in which low-density lipoprotein (LDL) cholesterol, fatty liver and hepatocarcinoma displayed an autosomal dominant pattern of inheritance. Approach and Results. The proband was a 25 year-old female with low plasma cholesterol and hepatic steatosis. Low plasma levels of total cholesterol and fatty liver were observed in 10 more family members; 1 member was affected by liver cirrhosis and four more subjects died of either hepatocarcinoma or carcinoma on cirrhosis. To identify the causal mutat…
SGK-1 protects kidney cells against apoptosis induced by ceramide and TNF-α
AbstractCeramide regulates several different cellular responses including mechanisms leading to apoptosis. Serum- and glucocorticoid-inducible protein kinase (SGK)-1 is a serine threonine kinase, which activates survival pathways in response to stress stimuli. Recently, we demonstrated an anti-apoptotic role of SGK-1 in human umbilical endothelial cells treated with high glucose. In the present study, since ceramide induces apoptosis by multiple mechanisms in diabetes and its complication such as nephropathy, we aimed to investigate whether SGK-1 may protect even against apoptosis induced by ceramide in kidney cells. Human embryonic kidney (HEK)-293 cells stable transfected with SGK-1 wild …
FAMILIAL LIGAND-DEFECTIVE APOLIPOPROTEIN B: IDENTIFICATION OF A FAMILY HARBOURING THE ARG3531CYS (FDB3531) OF THE APOB GENE
PCSK9-D374Y mediated LDL-R degradation can be functionally inhibited by EGF-A and truncated EGF-A peptides. An in vitro study
Accumulation of apoE-enriched triglyceride-rich lipoproteins in patients with coronary artery disease.
Triglycerides (TGs) are vehicled by multiple particles with different abilities to promote atherosclerosis. Among plasma TG-rich lipoproteins (TRLs), subspecies may or may not contain apolipoprotein E (apoE) molecules: in this study, we evaluated the relative contribution of apoE-rich and apoE-poor TRLs to coronary atherosclerosis. We selected a group of males with premature coronary artery disease (CAD) without any of the classical nonlipid risk factors and/or high plasma lipid levels and evaluated the plasma concentration of TRL subspecies in comparison with healthy controls. Patients with CAD and controls had total cholesterol and TG levels within the normal range (despite slightly, even…
CEREBROTENDINOUS XANTHOMATOSIS: A SICILIAN FAMILY HARBOURING THE R362C MUTATION IN THE STEROL 27-HYDROXYLASE GENE
Relazione tra il size delle LDL e l’estensione della malattia vasale coronarica in 72 pazienti maschi sottoposti a coronarografia diagnostica
Descrizione di una famiglia siciliana con iper-alfa-lipoproteinemia con deficit di CETP
Accumulation of ApoE-containing triglyceride-rich lipoproteins in normolipidemic men with premature coronary artery disease
Studio epidemiologico “Ustica”: bassa prevalenza delle LDL aterogene in una popolazione mediterranea
ΒETA ARRESTIN-2: A NEW “ACTOR” IN THE LDL-R ENDOCYTOSIS?
Il diabete, la familiarita’ per malattie cardiovascolari e l’estensione della malattia vasale quali predittori degli eventi clinici ad 1 anno di follow-up post-PTCA
PREVALENCE OF METABOLIC SYNDROME IN A RURAL SICILIAN POPULATION AND RELATIONS WITH CLINICAL EVENTS: THE VENTIMIGLIA HEART PROJECT.
Description of a sicilian family with hyper-alpha-lipoproteinemia with deficit of CETP activity
Nonalcoholic fatty liver and metabolic syndrome in Italy: Results from a multicentric study of the Italian Arteriosclerosis society
Nonalcoholic fatty liver disease (NAFLD) is associated with all the components of metabolic syndrome (MS) and might to be considered an additional component of MS itself. The Italian Society for the Study of Atherosclerosis (SISA) in 2005 started a research project aimed to study the NAFLD, using ultrasound (US), in nondiabetic MS subjects matching at least one of the ATP III criteria for HDL-C or triglycerides [TG]. Prevalence of US-NAFLD and its associated risk factors and prevalence of hypertransaminasemia and its possible determinants were evaluated. NAFLD prevalence was 0.78. Men with steatosis compared to men without steatosis were younger (P < 0.05) with higher TG (P < 0.03), homeost…
Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants
Background One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are affecting the number of adults with diabetes. Methods We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis w…
Effetti della dialisi sul rischio cardiovascolare nei pazienti uremici: aumento delle particelle remnants
Le variazioni dei valori dell’assetto lipidico durante la risposta di fase acuta post-infarto miocardico acuto sono accompagnate da modifiche nel size delle LDL
A novel nonsense mutation in the cept gene in italian Hyperalphalipoproteinemic subjects
LDL size, density and receptor affinity variation during an oral load in mild hyper-triglyceridemic and normal subjects
Il polimorfismo genico del CD14 C(-260)>T non e’ un fattore di rischio per infarto miocardico acuto
Levels of b-sitosterol in a sicilian sample of hyper-cholesterolemic patients
Low prevalence of the atherogenic small, dense LDL in a mediterranean population. Nutrition, Metabolism and Cardiovascular Diseases
Accumulo di particelle aterogene remnants dopo la dialisi in pazienti uremici
Clinical predictors of adverse events in a 1 year follow-up study post-PTCA.
Correlazione in 309 pazienti coronaropatici tra i livelli di HDL-colesterolo e l’estensione della coronaropatia
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants
Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of rai…
Effects “beyond-cholesterol” of statins: simvastatin reduces the levels of atherogenic lipoproteins in patients with premature coronary artery disease
Bassa prevalenza delle LDL aterogene piccole e dense in una popolazione mediterranea
A NOVEL LOSS OF FUNCTION MUTATION OF PCSK9 GENE
Le LDL generate in fase post-prandiale dopo carico grasso presentano maggiore densita’, minore size e maggiore affinita’ per il recettore
Accumulo di VLDL/IDL contenenti ApoE in maschi normolipemici con cardiopatia ischemica precoce
Simvastatin reduces the levels of ApoE-containing triglyceride-rich lipoproteins in men with premature coronary artery disease
Accumulation of remnant-like particles in normolipidemic men with premature coronary artery disease
Variazioni delle sottofrazioni delle lipoproteine ricche in trigliceridi durante la dialisi in soggetti uremici
Lipoprotein-associated phospholipase A2 activity is increased in patients with definite familial hypercholesterolemia compared with other forms of hypercholesterolemia
Background and Aim: Lipoprotein-associated phospholipase A2(Lp-PLA2) plays a key role in atherosclerosis development. It is considered a marker of increased risk of cardiovascular disease (CVD) and plaque vulnerability. Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated plasma levels of low-density lipoprotein cholesterol and a higher prevalence of early CVD. Our aim was to evaluate the differences in Lp-PLA2activity in a population of hypercholesterolemic patients with and without definite FH. Methods and Results: Hypercholesterolemic patients were consecutively recruited. Definite FH was defined according to Dutch Lipid Clinic Network criteria â¥8. All pat…