0000000001193314
AUTHOR
K. Emrich
Worldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2)
Abstract Objective Ovarian cancer comprises several histological groups with widely differing levels of survival. We aimed to explore international variation in survival for each group to help interpret international differences in survival from all ovarian cancers combined. We also examined differences in stage-specific survival. Methods The CONCORD programme is the largest population-based study of global trends in cancer survival, including data from 60 countries for 695,932 women (aged 15–99years) diagnosed with ovarian cancer during 1995–2009. We defined six histological groups: type I epithelial, type II epithelial, germ cell, sex cord-stromal, other specific non-epithelial and non-sp…
Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries
BACKGROUND: Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequalities globally for several subtypes of childhood leukaemia. METHODS: Cancer registries participating in CONCORD were asked to submit tumour registrations for all children aged 0-14 years who were diagnosed with leukaemia between Jan 1, 1995, and Dec 31, 2009, and followed up until Dec 31, 2009. Haematological malignancies were defined by morphology codes in the International Classification of Diseases for …
Tierexperimentelle Thioacetamid-Leberschäden unter therapeutischen Sulfonylharnstoffgaben (D 860)
Mit Thioacetamidbelastungen verschiedener Dauer experimentell lebergeschadigte Ratten wurden in verschiedenen Versuchsgruppen zusatzlich mit Sulfonylharnstoffgaben behandelt. Eine Intensivierung der Thioacetamidleberschaden durch Sulfonylharnstoffe konnte am histologischen Substrat in keinem Falle objektiviert werden. Nach 4wochiger Thioacetamidbelastung ergab sich bei der histologischen Untersuchung kein sicherer Anhalt dafur, das durch Sulfonylharnstoffgaben die Leber der behandelten Tiere vor experimentell erzeugten Leberschaden wesentlich geschutzt wird. Lediglich bei kurzfristiger Thioacetamidbelastung von 6tagiger Dauer lies sich eine gewisse protektive Wirkung der gleichzeitigen Sulf…