PREDICTORS OF RESIDUAL VEIN THROMBOSIS AFTER CANCER-RELATED DEEP VEIN THROMBOSIS OF THE LOWER LIMBS

Structure and form. Changes of state in architecture – from modern to contemporary

The relationship between the terms Structure and Form, while expressing a consideration on the tectonic component of composition, registers a cyclical evolution of the archi-tecture of the building. The solidity of the Modern, the liquidity of "post-modern conditions", the evaporation of the contemporary aesthetics of disappearance outline a return to a solid state of the matter outlining the basic assumption of formal research in architecture in the sculptural mass of the building.

Implementation of preventive and predictive BRCA testing in patients with breast, ovarian, pancreatic, and prostate cancer: a position paper of Italian Scientific Societies

Constitutional BRCA1/BRCA2 pathogenic or likely pathogenic variants (PVs) are associated with an increased risk for developing breast and ovarian cancers. Current evidence indicates that BRCA1/2 PVs are also associated with pancreatic cancer, and that BRCA2 PVs are associated with prostate cancer risk. The identification of carriers of constitutional PVs in the BRCA1/2 genes allows the implementation of individual and family prevention pathways, through validated screening programs and risk-reducing strategies. According to the relevant and increasing therapeutic predictive implications, the inclusion of BRCA testing in the routine management of patients with breast, ovarian, pancreatic and…

Lung cancer incidence in young women (20-49 years) reached incidence in young men

Il grafico, basato sui dati AIRTUM 1992- 2007,mostra l’andamento dell’incidenza di tumore del polmone nei giovani adulti di età 20-49 anni in entrambi i sessi. I

Liquid biopsies in lung cancer: The new ambrosia of researchers

Abstract: In the last decades the approach to cancer patient management has been deeply revolutionized. We are moving from a "one-fits-all" strategy to the "personalized medicine" based on the molecular characterization of the tumor. In this new era it is becoming more and more clear that the monitoring of the disease is fundamental for the success of the treatment, thus there is the need of new biomarker discovery. More precisely in the last years the scientific community has started to use the term "liquid biopsy". A liquid biopsy is a liquid biomarker that can be easily isolated from many body fluids (blood, saliva, urine, ascites, pleural effusion, etc.) and, as well as a tissue biopsy,…

In 2014 cancer registration covers more than half of the Italian population [Nel 2014 la registrazione dei tumori in Italia è estesa a oltre la metà del Paese]

After the increasing trend in the Nineties, in Italy incidence of tumours in children (0-14 years) is decreasing [Dopo l'aumento registrato negli anni Novanta, in Italia l'incidenza dei tumori infantili (0-14 anni) è in diminuzione]

Ruolo dell'elastonosonografia nella valutazione del tendine achille dopo infiltrazione con pappa piastrinica nostra esperienza .

Ruolo dell'elastosonografia nella valutazione del tendine di achille dopo infiltrazione con pappa piastrinica nostra esperienza su 10 casi

Novel P53 mutations detected by FAMA in colorectal cancers

Background The aim of the study was to identify p53 gene mutations by FAMA (fluorescence-assisted mismatch analysis) in colorectal cancers. Patients and methods Analytical scanning of the p53 gene (exons 5–9) was performed in colon cancer samples from 44 consecutive patients by FAMA. FAMA is a semiautomatic scanning approach based on the chemical cleavage of the mismatch in fluorescently labeled heteroduplex DNA, obtained from the combination of a normal and a mutated allele. FAMA has already shown optimal levels of diagnostic accuracy and sensitivity in detecting gene mutations (nucleotide substitutions, insertions/deletions) both at the germline and somatic level. The peculiar feature of …

Second-line treatment in exon 11-mutated GIST patients: Imatinib dose escalation or sunitinib? Retrospective analysis of a multi-institutional experience.

10515 Background: Data from metastatic GIST patients harbouring exon 11 mutation who received a second line treatment with sunitinib or imatinib dose escalation were retrospectively analysed to compare survival. Methods: 123 exon 11 mutated advanced GIST patients were included. All patients progressed on imatinib 400 mg/die and received, on discretion of physician, a second line treatment with either imatinib (800 mg/die) or sunitinib (50 mg/die 4 weeks on/2 weeks of or 37.5 mg/day continuous daily dose). The type of exon 11 mutation was recorded (deletion versus others) and correlated with survival and response according to RECIST or CHOI criteria Results: 79 patients (64%) received a seco…

Paragangliomi cervicali: diagnosi e trattamento

Chemical composition and anticancer activity of essential oil of Mediterranean sage (Salvia officinalis L.)

SUBINTIMAL RECANALIZATION AND STENTING FOR LONG SUPERFICIAL FEMORAL ARTERY OCCLUSIONS

Objective: To assess the feasibility and mid-term outcome of combined subintimal recanalization and stenting for the treatment of long superficialFebruary, and then Protégé® EverFlexTM) were placed in the whole subintimal space. The number and the length of stents was dictated from the length of the intentional subintimal dissection. The site of re-entry was chosen without compromise the feasibilty of a future bypass grafting. When completion arteriogram revealed residual stenosis, a post-dilatation was performed. Results: Twenty-eight patients (90.3%) underwent successful procedures, whereas two attempts failed because of inability to pass the guidewire through SFA occlusion and one becaus…

In the last 15 years, survival in Italian children (0-14 years) is increased to 12%. [Negli ultimi 15 anni la sopravvivenza per tumore nei bambini italiani di età 0-14 anni è aumentata del 12%]

About 1,400 new cancer diagnosis in Italian children (0-14 years) are attended every year (7,000 in 5 years) [Ogni anno sono previste circa 1.400 nuove diagnosi di tumori maligni nei bambini italiani di età 0-14 anni (7.000 nel quinquennio)]

P16 ink4A, p53 alterations and S phase fraction are predictive of clinical outcome in laryngeal squamous cell carcinoma.

Trattamento delle steno-ostruzioni della biforcazione aorto-iliaca mediante la tecnica "kissing-stents"

Study of Cellular DIMA Content by Flow Cytometry in Primary Bladder Carcinomas

A prospective study of cellular DNA content by flow cytometry was performed on a nonconsecutive series of 67 patients undergoing diagnostic and/or therapeutic transurethral resection for primary urothelial bladder carcinoma. DNA-aneuploidy was present in 82% of the cases (55/67), while multiclonality was found in 45% of the DNA-aneuploid cases (25/55). DNA-ploidy was much more strictly correlated with histological grading (p less than 0.005) than with papillary or non-papillary growth pattern (p less than 0.05) or T staging (p less than 0.05). Of 26 patients with a minimum follow-up of 24 months, 100% (6/6) of cases with DNA-diploid neoplasias showed no signs of disease relapse, versus 10% …

Parco Agricolo del Gugliotta a Piano Tavola,Carini.Nuove relazioni tra tessuto urbano e tessuto agricolo

Progetto per Carini Ricerca PRIN MIUR UNIPA

Efficacy and safety of first-line checkpoint inhibitors-based treatments for non-oncogene-addicted non-small-cell lung cancer: a systematic review and meta-analysis

Background: Frontline immune checkpoint inhibitors (ICI)-based regimens in non-oncogene-addicted non-small-cell lung cancer (NSCLC) have been deeply investigated. To rank the available therapeutic options, we carried out a systematic review and Bayesian meta-analysis. Methods: A comprehensive search for randomized controlled trials (RCTs) of ICI regimens, and a pairwise and a network meta-analysis (NMA) with an all-comers and a stratified strategy were conducted. Endpoints were overall survival (OS), progression-free survival (PFS), objective response rate (ORR) and treatment-related adverse events (TRAEs). Results: Nineteen RCTs involving 17 treatment regimens were included. For the all-co…

Urbano non urbano. Progetto di centro intermodale a Castelvetrano

La proposta progettuale si colloca in un’area di circa 120.000 mq in prossimità della stazione ferroviaria di Castelvetrano, tra l’attuale linea ferrata e l’ex sede ferroviaria; una zona che presenta un indebolimento della forma urbana conseguente all’espansione della città dentro il territorio agricolo. Il progetto mira alla riqualificazione di tale area e dove possibile anche alla rifunzionalizzazione di alcuni edifici dismessi appartenenti alla ferrovia. Nell’ambito di un’ eventuale più ampia proposta progettuale di collocare lungo la linea ferrata gli edifici di un centro intermodale volto alla valorizzazione delle vocazioni produttive del comune di Castelvetrano, nonché dei comuni limi…