Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to rveal 5-HT1a receptor function

Central GABAergic and serotoninergic systems interact with one another and are implicated in controlling different behaviours. A gentle early long-lasting handling can prevent the deficits in locomotion and exploration in open field (O.F.) in 3-month-old male rats prenatally exposed to diazepam (DZ). Purpose of this study was to extend the research to older handled rats prenatally exposed to DZ and to assess the activity of 5-HT1A receptors (Rs), evaluating the performance in O.F. at 3 and 18 months of age following 8-OH-DPAT administration. A single daily s.c. injection of DZ (1.5 mg/kg) from gestation day 14 to gestation day 20 induced in aged, but not in young rats, a decrease in total d…

Farmacologia Generale

Behavioural stress reactivity in handling naive and handling-habituated adult male rats prenatally exposed to different benzodiazepine receptor agonists

Benign Prostatic Hyperplasia: Correlations between Receptor Density and Binding Affinity of 1-Adrenoceptors and Several Clinical Parameters

The aim of the study was to determine whether relations do exist between the concentration and activity of 1-adrenoceptors, both inside the prostatic adenoma and the periurethral zone corresponding to the bladder neck, and clinical and biological parameters such as symptoms, evaluated by the American Urological Association (AUA) score, age, weight of the prostate, PSA, and the flow rate. Twenty patients with symptomatic benign prostatic hyperplasia were selected for an open prostatectomy. One gram of tissue was dissected from inside the adenoma and 1 g from the periurethral zone corresponding to the bladder neck. The 1-adrenoceptors were evaluated for the apparent dissociation constant (Kd)…

Functional study of GABA-A receptors located on noradrenergic nerve endings in the rat hippocampus following prenatal exposure to diazepam