0000000001198023
AUTHOR
Eric Brouwer
showing 4 related works from this author
Diagnostic accuracy of a fully automated multiplex celiac disease antibody panel for serum and plasma.
2019
Abstract Background An automated multiplex platform using capillary blood can promote greater throughput and more comprehensive studies in celiac disease (CD). Diagnostic accuracy should be improved using likelihood ratios for the post-test probability of ruling-in disease. Methods The Ig_plex™ Celiac Disease Panel on the sqidlite™ automated platform measured IgA and IgG antibodies to tTG and DGP in n = 224 CD serum or plasma samples. Diagnostic accuracy metrics were applied to the combined multiplex test results for several CD populations and compared to conventional single antibody ELISA tests. Results With multiple positive antibody results, the post-test probability for ruling-in untrea…
Multi-response kinetic modelling of the formation of five Strecker aldehydes during kilning of barley malt
2022
Strecker aldehydes are responsible for the characteristic aroma of malts, but also important aroma compounds in beer. In malt, they are formed during the curing stage of kilning. The formation of five Strecker aldehydes (2-methylpropanal, 2-methylbutanal, 3-methybutanal, phenylacetaldehyde and methional) during this process was studied at pilot scale. Green malts were dried and cured at different temperatures (65, 78 and 90 °C) isothermally for 8.4 h. Multi-response kinetic modelling was used to develop a mathematical model based on precursors concentration, Amadori rearrangement products (ARP), Strecker aldehydes, temperature and time. This model demonstrated that the formation of Strecker…
Efecto del método de cálculo y de la presencia de falsos positivos en los umbrales de percepción
2023
El objetivo de este trabajo ha sido demostrar que, a la hora de calcular umbrales de percepción, el método de cálculo elegido y las respuestas que son falso positivo (es decir, aquéllas en las que la respuesta positiva no corresponde a la detección real del aroma sino al azar al elegir la respuesta), tienen un efecto significativo sobre el valor de umbral calculado.
Effect of calculation methods and presence of false positives on perception thresholds
2023
Perception thresholds are commonly used in food science to discriminate between those compounds that are more or less odour-active. It is not rare to use values from other studies and apply them to our data, however, we observed that the procedure to evaluate and calculate perception thresholds is not standardised. The aim of this study was to explore the influence of calculation methods on threshold values. To do so, we used a 3-AFC sensory procedure to determine the orthonasal and retronasal detection values of 26 compounds, amongst them some compounds that usually contribute to the aroma of strawberry and caramel (e.g. vanillin, Furaneol and damascenone). The thresholds were calculated b…