0000000001211923
AUTHOR
Lucina Titone Lanza Di Scalea
Enterite da Noravirus nei bambini ospedalizzati a Palermo
Bone Mineral Status in HIV infected Patients in Mediterranean Region: Preliminary Data
Efficacia e tollerabilità dell'associazione caspofungin/amphotericina B liposomiale in pazienti con candidosi
Considerazioni su un caso di schizosomiasi urinaria
Leprosy-like cutaneous presentation of Histoplasma capsulatum infection in an African HIV+ patient
Histoplasma capsulatum is an opportunistic dimorphic fungus responsible for most often self-limiting or flu-like infections but potentially lethal in immunocompromised hosts. Histoplasmosis is rare in Europe. We reported a case of disseminated histoplasmosis in an African HIV patient with a leprosy-like primary cutaneous presentation and involvement of lungs, brain, limphnodes and eye. The therapy with liposomial B amphotericin and itraconazole led to a prompt resolution of the symptoms.
Infezioni invasive da Candida in gravi prematuri
Un caso di infezione da Geotrichum capitatum
ThO to Th1 switch of CD4T cell clones specific from the 16-kDa antigen of Mycobacterium tuberculosis after successfull therapy: lack of involvement of epitope repertoire and HLA-DR
Cuteneous leishmaniasis (CL) in western Sicily
Analisi di costo-efficacia della vaccinazione universale in Italia con il vaccino Rix4414 contro i rotavirus [Cost-effectiveness of universal rotavirus vaccination with Rix4414 in Italy]
Objectives: Rotavirus (RV) is the most common etiological agent of gastroenteritis in children. The oral vaccine Rix4414 was recently commercialized in Italy for prevention of RV infections. The health outcomes and the economic impact of a national RV immunization program were assessed. Design: A Markov model simulated the flow of a birth cohort on RV disease burden and costs up to age 5, comparing a RV vaccination programme with no vaccination. Lifetime cost-effectiveness for the national healthcare system (NHS) and the society (S) with a benchmark of 50,000 €/QALY was analysed. Main results: Disease’s medical direct costs exceeded 30 million €/year, while indirect costs approached 112 mil…
Indagine clinico epidemiologica sulle enteriti infettive a Palermo II- Campylobacter: primi isolamenti in Sicilia occidentale
Assunzione di calcio e fattori di rischio comportamentali per la perdita di massa ossea in soggetti con o senza infezione da HIV residenti in un'area del Mediterraneo
Epatite virale acuta da HEV a Palermo: descrizione di un caso
Caratteristiche cliniche e di laboratorio di 415 bambini siciliani con febbre bottonosa del Mediterraneo (FBM).
Liver disease severity and low bone mineral density in HIV mono-infected and HIV/HCV co-infected patients
Background: In this study we assess: prevalence of osteopenia, osteoporosis and reduced bone mineral density in HIV infection and HIV / HCV co-infection;risk factors associated with reduced bone mineral density(BMD); relationship between bone mineral density and reduced liver fibrosis (FE) measured as "liver stiffness" (LS), by FibroScan ® in patients co-infected with HIV / HCV; relationship between reduced bone mineral density and cardiovascular risk assessed with the 10-year Framingham risk score (FRS) in HIV / HCV co-infected Patients And Methods: One hundred and ninety-four HIV-infected subjects (121 males =62% and 73 females = 38 %): 129 HIV-infected ( 66.5 % ) and 65 HIV / HCV co-infe…
Materno-fetal Toxoplasma gondii infection: critical review of available diagnotic methods
Indagine clinico epidemiologica sulle enteriti infettive a Palermo II- Camphylobacter: primi isolamenti in Sicilia occidentale
Procalcitonin levels in plasma in oncohaematologic patients with an without bacterial infections
BACKGROUND: The flogosis markers currently in use show both low sensitivity and specificity, particularly in neoplastic and degenerative diseases. Procalcitonin (PCT) is a pro-peptide of calcitonin produced mainly but not only in the C-cells of the thyroid glands and, as several studies show, PCT levels in plasma increase during infections. Bacterial infections are also the main cause of death in oncological patients. Furthermore, in patients with leukaemia in chemotherapy recovery, infections often induce relapses. The aim of the present study is to detect PCT levels in plasma in oncohaematologic patients with and without infections. METHODS: The study was carried out on 54 patients by a q…
Pulmonary tuberculosis in Italian children by age at presentation
Infezione materno-fetale da toxoplasma gondii: analisi critica della diagnosi pre e post-natale
Un caso di linfoma cardiaco primitivo in paziente HIV-NAIVE
Surveillance of Varicella in the Sicilian Pediatric Population Following in the Introduction of Universal Vaccination
Rickettsiosi gravi
Un caso di Febbre Bottonosa del Mediterraneo (FBM) complicata da insufficienza renale acuta ed esofagite erpetica
One-year surveillance of methicillin-resistant Staphylococcus aureus in health-care setting, Palermo, Italy
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is an emerging cause of infections outside of health care settings. We carried out a survey to determine the prevalence and characteristics of MRSA isolates (CA-MRSA, HA-MRSA) identified among in- and outpatients by the clinical microbiology laboratories of four general hospitals in Palermo, Italy during the period February-January 2010. Methods: Participating laboratories performed isolation, confirmed methicillin-resistance by their routine method and weekly sent their strains to the coordinating laboratory at the Department of Sciences for Health Promotion “G. D’Alessandro”, University of Palermo, Italy. The isolates were tes…
Utilità della PCR su sangue periferico (SP) nella diagnosi di leishmaniosi viscerale (LV): esperienza di 8 anni.
INFEZIONE POLMONARE DA BLASTOSCHIZOMICES CAPITATUS
Geotrichum capitatum, now known as Blastoschizomyces capitatus, can be responsible for several opportunistic infections (systemic infection or localized at lungs, liver, kidney, encephalitis or meningitis) in an immunocompromised host, especially in those patients affected by leukaemia or under immunosuppressive therapies. A 66-year-old woman with polimyosite under steroid and immunosuppressant therapy was hospitalized in ICU for an acute respiratory distress with moderate hypoxaemia and normocapnia. Pulmonary X-ray revealed a bilateral pneumonia. Hypoxaemia became severe 48 hours later and the patient underwent mechanical ventilation and empirical antibiotic therapy. Blood cultures, urine …
Utilità della PCR su sangue periferico (SP) nella diagnosi di leishmaniosi viscerale (LV): esperienza di otto anni
Parassitosi emergente: la sindrome da LMV
Follow-up post natale in nati da madre con infezione certa da Toxoplasma gondii considerazioni sul management prenatale.
The clinical management of perinatal toxoplasmosis involves a gynaecologist during pregnancy and a neonatologist after delivery. Then, in the absence of a uniform approach, early evaluation of infected infants requires a thorough long-term follow-up also in asymptomatic children, who have to be observed for at least one year due to unpredictable sequelae in later life. We retrospectively analyzed pregnancy management of 54 women with certain infection from Toxoplasma gondii (TG) and prospectively enrolled their infants to compare prenatal management with postnatal clinical outcome. All mothers with seroconversion for TG infection were from the Palermo area and were retrospectively analyzed,…
Valutazione dell'attività apoptotica di alcuni 3,5-dimetossistilbeni naturali e di sintesi su Leishmania infantum
Effetti del trans-3,4',5-trimetossi-3'-amino-stilbene sul ceppo din Leishmania infantum MON1/IPT1
Analysis of the Polymorphisms of Th1 and Th17 Cytokines in Mediterranean Spotted Fever
Background: We have recently reported that the susceptibility for Mediterranean spotted fever (MSF) caused by Rickettsia conorii, is influenced by the Th2 and Th1 cytokine genetic polymorphism profiles. Less it is known on the effect of gene polymorphisms of cytokine produced by the Th17. Methods: 70 Sicilian patients affected by MSF and 239 control subjects matched for age, gender, and geographic origin were typed for functionally relevant single nucleotide polymorphisms (SNPs) of IFN-γ (+874 T/A), IL-18 (-137 G/C and -607A/C ) and IL-17 (7488T/C) according to our laboratory procedures. Results: No significant differences in IL-18 -137 G/C, -607A/C and in IFN-γ +874 T /A genotype frequenci…
Screening sierologico per l'infantum in soggetti HIV+ in area endemica Sicilia occidentale
Agenti zoonosici in specie esotiche: isolamento di chryseobacterium meningosepticum da un ascesso intraddominale in un alligatore americano
La spondilodiscite oggi: osservazioni su nove casi
Analysis of Polymorphism C558T of MAL (TIRAP) in Mediterranean Spotted Fever
Analysis of Polymorphism C558T of MAL (TIRAP) in Mediterranean Spotted Fever M. Bova1, L. Scola1, C. Colomba1, L. Vaccarino1, P. Di Gangi1, G. Santini1, G. Giammanco1, C. R. Balistreri1, D. Lio1, L. Titone Lanza Di Scalea1 1University of Palermo, Palermo, Italy Background: In our previous studies, we have demonstrated that cytokine polymorphisms, such as IFNγ +874T/A or IL-17 SNP (7488T/C), might interfere with R. Conorii infection control. In addition, we have reported that +896A/G TLR4 SNP is a component of a genetic background that might influence the clinical outcome of Boutonneuse fever (Mediterranean spotted fever, MSF). The +869G allele, that attenuates receptor signaling, was actual…
Circolazione di Gram-negativi produttori di ESBL in una unità di terapia intensiva neonatale.
Un caso di FBM neonatale in corso di un outbrek familiare
Surveillance of varicella in the Sicilian pediatric popolation following the introduction of universal vaccination
Efficacia della Claritromicina (CLA) nel trattamento degli episodi acuti di broncospasmo nei bambini con una storia di wheezing ricorrente
Considerazioni su un caso di schistosomiasi urinaria.
Urinary tract schistosomiasis is a parasitic disease caused by S. haematobium with a wide range of clinical manifestations related to the mucosal and submucosal granulomatous lesions of the bladder. It affects about 80 million people in Africa, Middle-East and India, while in Italy it is rarely seen among immigrants from endemic areas and returning travellers. The authors describe a case occurred in a 26 year old man, recently emigrated from a rural area of Ghana. He had the symptoms of a haemorrhagic cystitis. Cystoscopy and biopsy showed granulomatous lesions of bladder with calcified eggs. Microscopic examination of urine was positive for Schistosoma haematobium eggs. The therapy with Pr…
Coverage survey of the Sicilian pediatric population following the introduction of universal varicella vaccination
Stipiti di Pseudomonas aeruginosa MBL produttori in Unità di Terapia Intensiva Neonatale (UTIN)
Il ruolo di Campylobacter spp quale agente di enterite in Sicilia Occidentale. Considerazioni su 35 casi
Introduction: Campylobacter spp is the main cause of bacterial gastroenteritis in the developed countries, resulting mainly from the contamination of poultry and animal products. Pathogenesis remains unclear. Various clinical features ranging from watery diarrhoea in apyrexia to dysentery in hyperpyrexia may be the result of differences between strains in the expression of different pathogenetic factors. There are many difficulties in isolating the bacteria in question. Methods: We processed 540 faecal specimens of children with gastroenteritis. We detected enteropathogen bacteria including Campylobacter spp as well as Rotavirus, Adenovirus and protozoans. For the isolation of Campylobacter…
Efficacia e tollerabilità di piperacillina/tazobactam in profilassi preoperatoria
Rhabdomyolysis associated with the co-administration of daptomycin and pegylated interferon α-2b and ribavirin in a patient with hepatitis C
Follow-up diagnostico di bambini con sospetta toxoplasmosi connatale: valutazioni preliminari
Mucormicosi cutanea primitiva: descrizione di un caso clinico
Indagine clinico-epidemiologica sulle enteriti infettive a Palermo:II- Le infezioni da Salmonella
Endocrine, auxological and clinical follow up of connatally HIV-infected children: personal experience
Enterite da Norovirus nei bambini ospedalizzati a Palermo
Prevalence of Toscana sand fly virus antibodies in neurological patients and control subjects in Sicily
Toscana sandfly fever virus (TOSV) is an arthropod-borne virus transmitted to humans by sandfly vectors. It has been associated with human cases of meningitis and meningo-encephalitis mainly occurring during the warm season. We performed a retrospective serological study to evaluate TOSV circulation in Palermo, Sicily, and to compare TOSV seroprevalence in patients with neurological symptoms and in a control group of patients without neurological symptoms. When sera from 155 patients with and without neurological symptoms were evaluated, the rate of overall TOSV IgG reactivity was 17.4%. Patients with neurological symptoms showed a higher percentage of TOSV IgG positivity than control patie…
I database regionali ICD9-CM costituiscono uno strumento utile ed efficace per stimare i ricoveri ospedalieri prima e dopo l'introduzione della vaccinazione anti-rotavirus in Italia
Circulating varicella-zoster virus strains in european chickenpox outbreacks and its implications regarding a universal vaccination policy.
TBC, LUE e AIDS in immigrati extracomunitari. Considerazioni su tre casi
Piperacillina/tazobactam in terapia empirica
Leishmaniosi viscerale e sindrome di Down:descrizione di un caso clinico
Infezione criptica da Leishmania Infantum in pazienti italiani con infezione da HIV
Mediterranean visceral leishmaniasis in immunocompetent children. Report of two cases relapsed after specific therapy
Visceral leishmaniasis (VL) is endemic in areas bordering the Mediterranean Sea (Spain, Italy, France, Greece, Morocco, Tunisia) where it is caused by Leishmania infantum and is transmitted by the bite of a hematophagous sandfly belonging to Phlebotomus spp.; the dog constitutes the main reservoir of infection. Two cases of VL in immunocompetent children are described. Both patients lived in endemic areas for leishmaniasis (Sicily) and at admission were febrile, pale and had splenomegaly. In both patients anti-leishmania antibodies were present and a definitive diagnosis was confirmed by demonstration of leishmania parasites by microscopy or polymerase chain reaction (PCR) in the bone marro…