Cadmium accumulation induces apoptosis in sea urchin embryos and larvae

Cadmium induces an apoptotic response in sea urchin embryos.

Cadmium is a heavy metal toxic for living organisms even at low concentrations. It does not have any biological role, and since it is a permanent metal ion, it is accumulated by many organisms. In the present paper we have studied the apoptotic effects of continuous exposure to subacute/sublethal cadmium concentrations on a model system: Paracentrotus lividus embryos. We demonstrated, by atomic absorption spectrometry, that the intracellular amount of metal increased during exposure time. We found, using terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay, that long treatments with cadmium triggered a severe DNA fragmentation. We demonstrated, by immunocytochemistry …

Cadmium effects on sea urchin embryos

Apoptotic pathway induced by cadmium in sea urchin embryos

Cadmium insult and defence mechanisms in Paracentrotus lividus embryos and larvae.

Cadmium accumulation induces apoptosis in P. lividus larvae.

Apoptosis during early development of sea urchin.

Apoptosis is a genetic program of cell death that eliminates superfluous or compromised cells during development and adult life of many organisms. In sea urchin embryos, apoptosis is not only a physiological event during larval metamorphosis, but also a process induced by cadmium accumulation or other stressor like TPA (12-O-tetradecanoylphorbol-13-acetate) followed by an increase of temperature to 31°C. Apoptosis is a highly conserved process usually operated by a proteolytic cascade that involves caspase activation by two different pathways: extrinsic and intrinsic. The first one involves membrane death receptors, while the second involves mitochondria. In this work we analyzed the possib…

Induction of apoptosis by cadmium in Paracentrotus lividus embryos and larvae

Induction of apoptosis by cadmium in sea urchin embryos: possible involvement of extrinsic pathway

Response to cadmium stress in sea urchin embryos

Risposta da stress in embrioni di Paracentrotus lividus esposti a cadmio

Physiological and cadmium induced apoptosis in Paracentrotus lividus larvae

Effetti del cadmio sugli embrioni di riccio di mare

New therapeutic prospects in HCV treatment.

Differences beetween physiological and induced apoptosis in sea urchin embryos.

Stress induced and physiological apoptosis during early development of sea urchin Paracentrotus lividus.

Cadmium induces apoptosis in P. lividus embryos

Apoptotic pathway in sea urchin embryos

Apoptosi in larve di Paracentrotus lividus.