SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…

INTEGRATED CALCAREOUS PLANKTON BIOSTRATIGRAPHY OF SELECTED MIOCENE SUCCESSIONS IN THE NORTHERN CALABRIA (ITALY).

An integrated calcareous plankton biostratigraphic approach on six sections cropping out in Northern Calabria allowed to define a revised chronostratigraphic framework for Tortonian-Messinian deposits. Four sections have been investigated in the Amantea Basin (Timpone Napoli, Vallone Salina, Case Vespano, and Cozzo Salice) and two in the Rossano Basin (Vallone Casino and Cozzo Sant'Isidoro). Biostratigraphic analyses have been based on quantitative counting of planktonic foraminifers and semiquantitative counting of nannofossils. The Timpone Napoli and Vallone Salina sections are Late Tortonian in age and referable to the Globorotalia suterae Zone. In terms of nannofossils zonal scheme thes…

2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors.

Several 1,3-thiazolidin-4-ones bearing a 2,6-dihalophenyl group at C-2 and a substituted pyrimidin-2-yl ring at the N-3 were synthesised and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of human immunodeficiency virus type-1 (HIV-1) replication at 10–40 nM concentrations with minimal cytotoxicity. Structure–activity relationship studies revealed that the nature of the substituents at the 2 and 3 positions of the thiazolidinone nucleus had a significant impact on the in vitro anti-HIV activity of this class of potent antiretroviral agents. The compounds had significantly reduced activity against the characteristic N…

Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents

Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30-50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).

Design and synthesis of new HIV-1 NNRTIs