0000000001220425

AUTHOR

Giuseppe Mazzullo

showing 1 related works from this author

Mast cells in canine mammary gland tumour: number, distribution and EPOR positivity.

2011

Erythropoietin (EPO)-mediated mitogenic and anti-apoptotic effects involve all the cells expressing functional receptors for EPO (EPOR), as demonstrated by in vitro and in vivo studies. EPO shows pleiotropic effects and acts as an endogenous mediator of adaptive tissue response to metabolic stress protecting tissues from different injuries. Recently, the EPO/EPOR complex has been identified in several neoplastic cell lines and solid tumours. In this study, the authors investigated the mast cells (MCs) number, distribution and their immunoreactivity for EPOR in normal, dysplastic and neoplastic canine mammary gland. The results showed that MCs were more numerous in displastic glands compared…

Pathologymedicine.medical_specialtyMammary glandMammary glanddog; erythropoietin; mast cellsMammary Neoplasms Animalmast cellsBiologymedicine.disease_causeMast cellDogsEPO EPORmedicineAnimalsDog DiseasesReceptorSchools VeterinaryGeneral VeterinaryAnimalSettore MED/27 - NeurochirurgiaEPORfood and beveragesImmunohistochemistryEpitheliumErythropoietin receptormedicine.anatomical_structureOncologyItalySettore VET/03 - Patologia Generale E Anatomia Patologica VeterinariaErythropoietinembryonic structuresdogVeterinary (all)ImmunohistochemistryNeoplastic cellFemaleerythropoietinDog DiseaseCarcinogenesismedicine.drug
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