6533b86ffe1ef96bd12cd2b8

RESEARCH PRODUCT

Mast cells in canine mammary gland tumour: number, distribution and EPOR positivity.

Alessandra SfacteriaGiuseppe MazzulloB. MacrìGiovanni LanteriGiovanni Grasso

subject

Pathologymedicine.medical_specialtyMammary glandMammary glanddog; erythropoietin; mast cellsMammary Neoplasms Animalmast cellsBiologymedicine.disease_causeMast cellDogsEPO EPORmedicineAnimalsDog DiseasesReceptorSchools VeterinaryGeneral VeterinaryAnimalSettore MED/27 - NeurochirurgiaEPORfood and beveragesImmunohistochemistryEpitheliumErythropoietin receptormedicine.anatomical_structureOncologyItalySettore VET/03 - Patologia Generale E Anatomia Patologica VeterinariaErythropoietinembryonic structuresdogVeterinary (all)ImmunohistochemistryNeoplastic cellFemaleerythropoietinDog DiseaseCarcinogenesismedicine.drug

description

Erythropoietin (EPO)-mediated mitogenic and anti-apoptotic effects involve all the cells expressing functional receptors for EPO (EPOR), as demonstrated by in vitro and in vivo studies. EPO shows pleiotropic effects and acts as an endogenous mediator of adaptive tissue response to metabolic stress protecting tissues from different injuries. Recently, the EPO/EPOR complex has been identified in several neoplastic cell lines and solid tumours. In this study, the authors investigated the mast cells (MCs) number, distribution and their immunoreactivity for EPOR in normal, dysplastic and neoplastic canine mammary gland. The results showed that MCs were more numerous in displastic glands compared with normal and neoplastic glands. As far as the EPOR immunoreactivity is concerned, we did not observe MCs reaction on cancer, in contrast with previously published data where epithelium of neoplastic gland showed an increase in EPOR expression along with the neoplastic progression. Overall, our results might be suggestive for MCs role in oncogenesis and offer new insight regarding to the expression of EPOR in mammary gland cancer in dog.

yearjournalcountryeditionlanguage
2011-01-01
10.1111/j.1476-5829.2011.00277.xhttp://hdl.handle.net/11570/1917917