Syntesis, characterization and electrochemistry of Ru(III) complexes with several aminoacid ligands

Synthesis, chemical characterization and preliminary in vitro antitumor activity evaluation of new ruthenium(II) complexes with sugar derivatives

Abstract Three new complexes of Ru(II), namely [RuCl 2 (Glun-N,O) 2 ]Na 2 ( I ; Glun = glucosaminate), [RuCl 2 (1-Tglu)(EtOH) 2 ]Na ( II ; 1-Tglu = 1-thio-β- d -glucose) and [Ru 2 (EtOH) 6 (AL)Cl 4 ] ( III ; AL = 6′-aminolactose) were prepared from the same Ru(II) precursor, [RuCl 2 (DMSO) 4 ] (DMSO = dimethyl sulfoxide). The characterization of the complexes was carried out by elemental analysis, FT-IR, ES-MS, NMR, EXAFS and DFT calculations. The effectiveness of the complexes on metastatic melanoma A 375 was investigated. The results show that complex II is the most active species.

Structural characterization of triorganotin(IV) complexes with sodium fusidate and DFT calculations

Abstract Three new complexes of the steroid sodium fusidate (sodium 2-[(1 S ,2 S ,5 R ,6 S ,7 S ,10 S ,11 S ,13 S , 14 Z ,15 R ,17 R )-13-(acetyloxy)-5,17-dihydroxy-2,6,10,11-tetramethyl tetracyclo[8.7.0.0 2,7 .0 11,15 ] heptadecan-14-ylidene]-6-methylhept-5-enoate = (NaFusidate, Na FA )]), with triorganotin(IV) moieties have been prepared and investigated by conventional techniques as FTIR, Mossbauer, ESI-MS and NMR spectroscopy. The isolated compounds showed stoichiometries organotin(IV)/fusidate 1/1, R 3 Sn(IV) FA (R = Me, FA1 ; Bu, FA2 ; Ph, FA3 ). The ligand coordination sites were determined by FTIR spectroscopic measurements. In the complexes, the carboxylate group of the fusidate li…

Synthesis, structure and electrochemistry of ruthenium(III) complexes whith potential biological activity

New Ruthenium complexes with antitumoral activity

Synthesis, Structural characterization and Exafs investigations of new ruthenium(III) complexes.

Two new complexs of Ru(III) with glucosaminic acid and 1-Methyluracil, [RuCl2(Glun-N,O)2]H (I), (Glun-= glucosaminate); [RuCl4(1-MeU-N3)(DMSO)]H2.H2O (II), (1-MeU-= 1-Methyluracilate) were prepared from the same Ru(III) precursors, RuCl3•3H2O and [(DMSO)2H][trans-RuCl4(DMSO)2]. The characterization of the complexes have been carried out by elemental analysis, FT-IR, ES-MS, NMR and EXAFS.

How organotin(IV)(sulfonatophenyl) porphynate may activate the apoptotic pathways in melanoma cells?

Structural investigations on diorgano- and triorganotin(IV) derivatives of [meso-tetra(4-sulfonatophenyl)porphine]metal chlorides.

Abstract Several new complexes of organotin(IV) moieties with MCln[meso-tetra(4-sulfonatophenyl)porphine], (R2Sn)2MCln[meso-tetra(4-sulfonatophenyl)-porphinate]s and (R3Sn)4MCln [meso-tetra(4-sulfonatophenyl)porphinate]s, [M = Fe(III), Mn(III): n = 1, R = Me, n-Bu; Ph; M = Sn(IV): n = 2, R = Me, n-Bu] have been synthesized and their solid state configuration investigated by infrared (IR) and Mossbauer spectroscopy, and by 1H and 13C NMR in D2O. The electron density on the metal ion coordinated inside the porphyrin ring is not influenced by the organotin(IV) moieties bonded to the oxygen atoms of the side chain sulfonatophenyl groups, as it has been inferred on the basis of Mossbauer spectro…

studio della reattività del bromuro di 2-piridilmagnesio

Synthesis of copper(II) complexes of new carbon-scorpionate ligands

A set of new “carbon-based” scorpionate ligands based on S- and N-containing heterocyclic moieties have been synthesized. They offer the advantage of a higher stability with respect to the “classical” boron-based scorpionate ligands and also a certain degree of hydrophilicity. The synthesis of these ligands was accomplished by the coupling reaction of the N-methylimidazolyllithium with a suitable electrophilic partner. The reaction yield ranges from 40% to 65%. Preliminary results on the synthesis and characterization of the related copper(II) complex are also presented.

Carbocysteine degradation catalyzed by organotin(IV) compounds.

Novel metallic and organometallic based antiproliferative complexes: Integrated methodologies of evaluation

ATTIVITÀ CITOTOSSICA DEI COMPLESSI DIORGANOSTAGNO(IV)-N-ACETILCISTEINA SU CELLULE DI MELANOMA A-375.

Synthesis, structural investigation and biological activity of metal ions complexes of N-acetylcysteine and carbocysteine

Complessi di nuova sintesi di derivati della cisteina con ioni metallici

Synthesis of Ru(III) complexes with several N and S donor ligands

Sintesi e caratterizzazione di complessi metallici biomimetici del sito attivo di proteine di rane

Synthesis and characterization of diorganotin(IV)complexes with Phenothiazine class Drugs. Biological and Theoretical studies on cytotoxic activity

Hydrogen bonding patterns of 7,9-dimethylguanine and its transplatinum(II) complexes

Methylation at the N7 position is one of the most frequently naturally occurring modifications of guanosine. This alteration drastically changes the hydrogen bonding and acid–base properties of the guanine nucleobase. Here we show on the example of the model nucleobase 7,9-dimethylguanine that due to blockage of N7 of the purine ring, new hydrogen bonding patterns occur on the minor groove binding face of this nucleobase involving the ring nitrogen N3 and the exocyclic amino group N2H2. The free 7,9-dimethylguaninium ion and several transplatinum(II) complexes of the this ligand are presented and discussed. Methylation at N7 drastically changes the acid–base and hydrogen bonding properties …

Studi strutturali e indagini biologiche di nuovi complessi di rutenio(III) con 1- tioglucosio e 1-metiluracile

Computational studies of new metallic ions complexes of antioxidant dipeptides

Synthesis and characterization of some new ruthenium complexes with ligands of biological interest

Synthesis, chemical characterization and biological activity of new histone acetylation/deacetylation specific inhibitors: a novel and potential approach to cancer therapy

Three new triorganotin(IV) complexes of valproic acid (vp1, Me3Sn-valproate; vp2, Bu3Sn-valproate; vp3, Ph3Sn-valproate) have been synthesized and investigated by spectroscopic and biological methods. An anionic, monodentate valproate ligand was observed, ester-like coordinating the tin atom on a tetra-coordinated, monomeric environment. The structures, though, can distort towards a penta-coordination, as a consequence of a long range O center dot center dot center dot Sn interaction. Crystallographic and NMR findings confirm this situation both in solid state and solution. Biological finding evidenced a clear cytotoxic action of the complexes in hepatocellular carcinoma cell cultures: one …

Synthesis, structural investigation and biological activity of new diorganotin(IV) N-acetylcysteine Complexes.

New histone acetylation/deacetylation specific inhibitors: a novel and potential approach to cancer therapy

The acetylation status of histones is regulated in eukaryotes by two kinds of enzymes, histone acetyltransferases (HATs) and histone deacetylases (HDACs), which are responsible for acetylation and deacetylation of lysines residues in N-terminal tails of histone.[1] Thus acetylation, together with phosphorylation and methylation of N-terminal tail of histones, are involved in regulating fundamental processes, such as proliferation and cell death.[2-3] Sodium butyrate, which belongs together with valproic acid to the class of short chain fatty acids, was the first HDAC inhibitor (HDACI) to be identified.[1] Organotin compounds have various influences on physical function including the hormone…

Organometallic Complexes with Biological Molecules. Structural investigation of cis-diammineplatinum(II)-Porphyrin derivatives.

CCDC 830010: Experimental Crystal Structure Determination

Related Article: Ornella Pellerito, Cristina Prinzivalli, Elisabetta Foresti, Piera Sabatino, Michele Abbate, Girolamo Casella, Tiziana Fiore, Michelangelo Scopelliti, Claudia Pellerito, Michela Giuliano, Giulia Grasso, Lorenzo Pellerito|2013|J.Inorg.Biochem.|125|16|doi:10.1016/j.jinorgbio.2013.04.008