0000000001231041
AUTHOR
María Dolores Ortiz Masiá
Induction of CD36 and Thrombospondin-1 in Macrophages by Hypoxia-Inducible Factor 1 and Its Relevance in the Inflammatory Process
Inflammation is part of a complex biological response of vascular tissue to pathogens or damaged cells. First inflammatory cells attempt to remove the injurious stimuli and this is followed by a healing process mediated principally by phagocytosis of senescent cells. Hypoxia and p38-MAPK are associated with inflammation, and hypoxia inducible factor 1 (HIF-1) has been detected in inflamed tissues. We aimed to analyse the role of p38-MAPK and HIF-1 in the transcriptional regulation of CD36, a class B scavenger receptor, and its ligand thrombospondin (TSP-1) in macrophages and to evaluate the involvement of this pathway in phagocytosis of apoptotic neutrophils. We have also assessed HIF-1α, p…
Progastrin Represses the Alternative Activation of Human Macrophages and Modulates Their Influence on Colon Cancer Epithelial Cells
Macrophage infiltration is a negative prognostic factor for most cancers but gastrointestinal tumors seem to be an exception. The effect of macrophages on cancer progression depends on their phenotype, which may vary between M1 (pro-inflammatory, defensive) to M2 (tolerogenic, pro-tumoral). Gastrointestinal cancers often become an ectopic source of gastrins and macrophages present receptors for these peptides. The aim of the present study is to analyze whether gastrins can affect the pattern of macrophage infiltration in colorectal tumors. We have evaluated the relationship between gastrin expression and the pattern of macrophage infiltration in samples from colorectal cancer and the influe…
Caracterización funcional de MAP Quinasas del subgrupo C1 de plantas
RESUMEN En plantas, la señalización a través de las cascadas de MAP quinasas da lugar a un amplio número de respuestas celulares que incluyen la división y diferenciación celular, así como respuestas a estrés de origen abiótico o biótico (Mishra et al., 2006). Las MAP quinasas de plantas pueden ser clasificadas, en base a la similitud de la secuencia de aminoácidos, en cuatro grupos (A-D), cada grupo se ha clasificado a su vez en dos subgrupos (1 y 2). Se dispone de muy poca información acerca de los miembros del subgrupo C1 (Nakagami et al., 2005). Dentro de este grupo se encuentran Ntf3 de tabaco, PhMEK1 de petunia y PsMAPK2 de guisante. En Arabidopsis, el subgrupo C1 está constituido por…