0000000001232803

AUTHOR

Giuseppina Bonanno

showing 1 related works from this author

Transplantation of low dose CD34+KDR+ cells promotes vascular and muscular regeneration in ischemic limbs.

2004

Hematopoietic progenitor cell transplantation can contribute to revascularization of ischemic tissues. Yet, the optimal cell population to be transplanted has yet to be determined. We have compared the therapeutic potential of two subsets of human cord blood CD34+ progenitors, either expressing the VEGF-A receptor 2 (KDR) or not. In serum-free starvation culture, CD34+KDR+ cells reportedly showed greater resistance to apoptosis and ability to release VEGF-A, as compared with CD34+KDR- cells. When injected into the hind muscles in immunodeficient SCIDbg mice subjected to unilateral ischemia, a low number (10(3)) of CD34+KDR+ cells improved limb salvage and hemodynamic recovery better than a …

Pathologymedicine.medical_specialtyAngiogenesismedicine.medical_treatmentPopulationMuscle Fibers SkeletalIschemiaNeovascularization PhysiologicAntigens CD34ApoptosisRevascularizationBiochemistryMiceIschemiaGeneticsmedicineAnimalsHumansRegenerationeducationMuscle SkeletalMolecular Biologyeducation.field_of_studybusiness.industryRegeneration (biology)Stem CellsHemodynamicsKinase insert domain receptorExtremitiesmedicine.diseaseFetal BloodFibrosisVascular Endothelial Growth Factor Receptor-2TransplantationImmunologyStem cellbusinessBiotechnologyStem Cell TransplantationFASEB journal : official publication of the Federation of American Societies for Experimental Biology
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