Guiding Principles for Chronic Total Occlusion Percutaneous Coronary Intervention. A Global Expert Consensus Document

© American Heart Association, Inc.

Two-Stage Origin of K-Enrichment in Ultrapotassic Magmatism Simulated by Melting of Experimentally Metasomatized Mantle

The generation of strongly potassic melts in the mantle requires the presence of phlogopite in the melting assemblage, while isotopic and trace element analyses of ultrapotassic rocks frequently indicate the involvement of subducted crustal lithologies in the source. However, phlogopite-free experiments that focus on melting of sedimentary rocks and subsequent hybridization with mantle rocks at pressures of 1&ndash

Global Chronic Total Occlusion Crossing Algorithm

© 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC By-NC-ND License (http://creativecommons.org/licenses/by-nc-nd/4)

Acidic Co-Catalysts in Cationic Gold Catalysis.

A systematic study on the effects of Lewis or Bronsted acid co-catalysts in gold-catalyzed reactions was undertaken using representative reactions (O-, N-, and C-nucleophilic additions to alkynes). Through these reactions, it was demonstrated that an acidic co-catalyst can increase the catalyst turnover significantly, enabling practical reaction rates at competitive catalyst loadings (<1 mol %). Further investigation is currently underway to improve the understanding of the subtle principles underlying these experimental observations.

Metal-Free and User-Friendly Regioselective Hydroxyfluorination of Olefins

A simple, user-friendly, metal-free protocol for the regioselective anti-Markovnikov hydrofluorination of olefins using readily available and inexpensive reagents has been developed. This new approach displays a broader scope than previously reported methodologies and has been applied to the late-stage fluorination of a complex molecule, giving rise to a fluorosteroid derivative. The stereochemistry of the process has also been studied in some detail.

O-7 FOLFIRI ± napabucasin in patients with previously treated metastatic colorectal cancer: Overall survival results from the phase 3 CanStem303C study

Global Chronic Total Occlusion Crossing Algorithm: JACC State-of-the-Art Review

© 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC-BY-NC-ND license.