0000000001251744

AUTHOR

Aline Corrêa-abrahão

showing 3 related works from this author

Primary melanoma of the oral cavity: A multi-institutional retrospective analysis in Brazil

2020

Background Melanoma is an aggressive malignant tumor, rarely observed in the oral cavity. The aim of this study was to describe the clinicopathologic features of a series of oral melanomas. Material and Methods A retrospective descriptive study was performed. A total of 15,482 biopsy records from two oral and maxillofacial pathology services in Brazil were analyzed. All cases of oral melanomas were reviewed, and clinical, demographic, histopathological data, treatment, and follow-up status were collected. In addition, immunohistochemistry stains (pan-cytokeratin AE1/AE3, vimentin, α-SMA, CD45, S-100 protein, HMB-45, Melan A, and Ki-67) were performed. Results The series comprised of 5 males…

AdultMalemedicine.medical_specialtyProliferative indexOral cavitysurvivalOral and maxillofacial pathologyBiopsymedicineHumansMelanomaGeneral DentistryUNESCO:CIENCIAS MÉDICASAgedRetrospective StudiesOral Medicine and Pathologymedicine.diagnostic_testbusiness.industryResearchMelanomaMiddle Agedoral cancermedicine.diseaseDermatologyoral squamous cell carcinomamedicine.anatomical_structureOtorhinolaryngologyImmunohistochemistryFemaleMouth Neoplasmshead and neck cancerSurgeryprognosisHard palatebusinessEpithelioid cellBrazilMedicina Oral Patología Oral y Cirugia Bucal
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An in vitro study showing the three-dimensional microenvironment influence over the behavior of head and neck squamous cell carcinoma

2011

Objectives: The Head and Neck Squamous Cell Carcinoma (HNSCC) ranks sixth worldwide. The mechanisms of growth, invasion and metastasis of this pathology are extensively studied and generally related to specific variations in signaling pathways like the PI3K-Akt; however most of these competent studies have been performed bidimensionally, which may hide important questions. This study sought to analyze the influence of the microenvironment upon the behavior of HNSCC. Study Design: The status of pAkt, NF-κB and Cyclin D1 proteins was accessed through immunofluorescence and western blot methods in HNSCC cell lines originating from tongue, pharynx and metastatic lymph node when submitted to a t…

Pathologymedicine.medical_specialtyImmunofluorescenceMetastasisCyclin D1Western blotTumor Cells CulturedTumor MicroenvironmentmedicineHumansCyclin D1Epidermal growth factor receptorGeneral DentistryOral Medicine and Pathologymedicine.diagnostic_testbiologySquamous Cell Carcinoma of Head and NeckNF-kappa B:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseHead and neck squamous-cell carcinomaOtorhinolaryngologyHead and Neck NeoplasmsCell cultureUNESCO::CIENCIAS MÉDICASCarcinoma Squamous CellCancer researchbiology.proteinResearch-ArticleSurgerySignal transductionProto-Oncogene Proteins c-aktMedicina Oral Patología Oral y Cirugia Bucal
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Oral pigmented lesions:a retrospective analysis from Brazil

2020

Background Pigmented lesions are uncommon in the oral mucosa, and studies investigating the incidence and types of these lesions are desired to improve the diagnostic knowledge of clinicians. The aim of this study was to analyze the distribution of oral pigmented lesions in a Brazilian population. Material and Methods A retrospective descriptive cross-sectional study was performed. Oral pigmented lesions were retrieved from the files of two oral and maxillofacial pathology services from Brazil over a 45-year period (1974-2019). The clinical data and the diagnoses of each case were retrieved and included in a Microsoft Excel® database. Results From 77.074 lesions diagnosed in this period, 76…

squamous cell carcinomamedicine.medical_specialtymalignant transformationLesionDiagnosis Differentialpotentially malignant disordersOral and maxillofacial pathologymedicineNevusHumansOral mucosaGeneral DentistryUNESCO:CIENCIAS MÉDICASRetrospective StudiesOral Medicine and Pathologybusiness.industryMelanotic neuroectodermal tumor of infancyResearchAmalgam tattooMouth Mucosamedicine.diseaseDermatologyMelanoacanthomaMelanosismedicine.anatomical_structureCross-Sectional StudiesOtorhinolaryngologyleukoplakiaSurgeryFemalemedicine.symptombusinessMouth DiseasesBrazil
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