0000000001252987
AUTHOR
C. Benz
Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes
Background/aims The accumulation of endogenous bile acids contributes to hepatocellular damage during cholestatic liver disease. To evaluate the potential role of apoptotic cell death due to increased concentrations of bile acids, primary human hepatocytes were treated with hydrophobic and hydrophilic bile acids. Because the Fas receptor–ligand system may mediate apoptosis in human liver cells, the effect of toxic bile acids on hepatocellular Fas receptor expression was evaluated. Materials and methods Primary human hepatocytes were incubated with 50 and 100 μM glycochenodeoxycholic acid (GCDCA) and co-incubated with equimolar concentrations of tauroursodeoxycholic acid (TUDCA). To evaluate…
Fabrication and characterization of graphene field effect transistors (GFET)
Graphene is a flat monolayer of carbon atoms tightly packed into a two-dimensional (2D) honeycomb lattice. This peculiarity is responsible of extraordinary physical properties. Graphene exhibits a strong ambipolar field effect and thanks to its huge charge carrier mobility, graphene is a suitable material for high frequency Electronics. Graphene field effect transistors (GFET) for high frequency applications have recently received much attention and significant progress has been achieved in this area. GFETs have been already made by using pre-patterned metal or graphene nanoribbon (GNR) back-gates and hexagonal boron nitride as a dielectric spacer. Among the most employed techniques for the…