0000000001253522

AUTHOR

Belén López

showing 4 related works from this author

Response to "Is the Reg3α (HIP/PAP) Protein Really an Obesogenic Factor?"

2015

Peer Reviewed

Male0301 basic medicinePhysiologyClinical BiochemistryeducationMEDLINEPancreatitis-Associated ProteinsBiologyClinical biochemistry03 medical and health sciences0302 clinical medicineAnimalsHumansObesityPancreatitis-Associated ProteinsAnimalProteinMedicine (all)ProteinsCell BiologyBlood coagulation factorsBlood Coagulation Factors030104 developmental biology030220 oncology & carcinogenesisProteins metabolismImmunologyFemaleBlood Coagulation FactorHuman
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Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers

2023

Acknowledgements: The authors thank G. Marciani and O. Jöris for comments on archaeology; C. Jeong, M. Spyrou and K. Prüfer for comments on genetics; M. O’Reilly for graphical support for Fig. 5 and Extended Data Fig. 9; the entire IT and laboratory teams at the Department of Archaeogenetics of MPI-SHH for technical assistance; M. Meyer and S. Nagel for support with single-stranded library preparation; K. Post, P. van Es, J. Glimmerveen, M. Medendorp, M. Sier, S. Dikstra, M. Dikstra, R. van Eerden, D. Duineveld and A. Hoekman for providing access to human specimens from the North Sea (The Netherlands); M. D. Garralda and A. Estalrrich for providing access to human specimens from La Riera (S…

HistoryAncient dnaInteractionsCave/45/23AdmixtureSettore BIO/08 - Antropologia/631/208/457/631/181/276160 Other humanitiesContaminationHumansHuntingPalaeogenomicsPopulation-structureArchaeology ; Biological anthropology ; Evolutionary genetics ; Population geneticsHistory AncientHuman evolutionDiversityOccupationMultidisciplinary/45Genome HumanarticlePaleontologyLast glacial maximumHuman GeneticsGene PoolGenomics/631/181/19/2471PleistoceneEuropeGenomic transformationsArchaeology/631/181/2474AnthropologyHunter-gatherersGenome sequence
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PAP/HIP Protein Is an Obesogenic Factor

2013

In this article we report the obesogenic role of the acute phase protein PAP/HIP. We found that the transgenic TgPAP/HIP mice develop spontaneous obesity under standard nutritional conditions, with high levels of glucose, leptin, and LDL and low levels of triglycerides and HDL in blood. Accordingly, PAP/HIP-deficient mice are skinny under standard nutritional conditions. We also found that expression of PAP/HIP is induced in intestinal epithelial cells in response to gavage with olive oil and this induction is AG490 sensitive. We demonstrated that incubation of 3T3-L1 preadipocytes with a low concentration as 1 ng/ml of recombinant PAP/HIP results in accelerated BrdU incorporation in vitro.…

medicine.medical_specialtyPhysiologybusiness.industryLeptinMEK inhibitorTransgeneClinical BiochemistryAcute-phase proteinAdipose tissueCell Biologymedicine.diseaseObesityIn vitroEndocrinologyInternal medicinemedicinePancreatitis-Associated ProteinsbusinessJournal of Cellular Physiology
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PAP/HIP protein is an obesogenic factor

2013

In this article we report the obesogenic role of the acute phase protein PAP/HIP. We found that the transgenic TgPAP/HIP mice develop spontaneous obesity under standard nutritional conditions, with high levels of glucose, leptin, and LDL and low levels of triglycerides and HDL in blood. Accordingly, PAP/HIP-deficient mice are skinny under standard nutritional conditions. We also found that expression of PAP/HIP is induced in intestinal epithelial cells in response to gavage with olive oil and this induction is AG490 sensitive. We demonstrated that incubation of 3T3-L1 preadipocytes with a low concentration as 1ng/ml of recombinant PAP/HIP results in accelerated BrdU incorporation in vitro. …

Transgenic micePAP/HIPSevere obesity
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