0000000001256790

AUTHOR

Alvaro Vela-souto

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Subventricular zone in motor neuron disease with frontotemporal dementia.

2011

Investigate how the subventricular proliferation and organisation is modified in a patient with FTLD-ALS. We studied the subventricular zone (SVZ) of a patient with FTLD-ALS immunohistochemical and histologically. We found an increase of Ki-67 positive cells and neuroblast in the subventricular zone, suggesting an activation of proliferating activity in response to FTD-ALS. This proliferation can act as a compensatory mechanism for rapid neuronal death and its modulation could provide a new therapeutic pathway in ALS. These results suggest a modification of neurogenesis in FTD-ALS. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

TelencephalonSubventricular zoneanimal diseasesNeurogenesisSubventricular zoneBiologyFrontotemporal lobar degenerationNeuroblastNeural Stem Cellsmental disordersmedicineHumansMotor neuron diseaseAmyotrophic lateral sclerosisMotor Neuron DiseaseAgedGeneral NeuroscienceNeurogenesisAmyotrophic Lateral Sclerosisnutritional and metabolic diseasesFrontotemporal lobar degenerationMotor neuronmedicine.diseaseNeural stem cellnervous system diseasesmedicine.anatomical_structurenervous systemFrontotemporal DementiaNerve DegenerationFemaleAmyotrophic lateral SclerosisNeuroscienceFrontotemporal dementiaNeuroscience letters
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