6533b871fe1ef96bd12d1223

RESEARCH PRODUCT

Subventricular zone in motor neuron disease with frontotemporal dementia.

Maria Sagrario Barquero JiménezJosé Manuel García-verdugoAlvaro Vela-soutoAlberto Rábano GutierrezLucía GalánJuan A. BarciaJorge Matías-guiuAntonio Guerrero-solaArmando Martinez-martinezUlises Gómez-pinedo

subject

TelencephalonSubventricular zoneanimal diseasesNeurogenesisSubventricular zoneBiologyFrontotemporal lobar degenerationNeuroblastNeural Stem Cellsmental disordersmedicineHumansMotor neuron diseaseAmyotrophic lateral sclerosisMotor Neuron DiseaseAgedGeneral NeuroscienceNeurogenesisAmyotrophic Lateral Sclerosisnutritional and metabolic diseasesFrontotemporal lobar degenerationMotor neuronmedicine.diseaseNeural stem cellnervous system diseasesmedicine.anatomical_structurenervous systemFrontotemporal DementiaNerve DegenerationFemaleAmyotrophic lateral SclerosisNeuroscienceFrontotemporal dementia

description

Investigate how the subventricular proliferation and organisation is modified in a patient with FTLD-ALS. We studied the subventricular zone (SVZ) of a patient with FTLD-ALS immunohistochemical and histologically. We found an increase of Ki-67 positive cells and neuroblast in the subventricular zone, suggesting an activation of proliferating activity in response to FTD-ALS. This proliferation can act as a compensatory mechanism for rapid neuronal death and its modulation could provide a new therapeutic pathway in ALS. These results suggest a modification of neurogenesis in FTD-ALS. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

yearjournalcountryeditionlanguage
2011-01-01Neuroscience letters
10.1016/j.neulet.2011.05.019https://pubmed.ncbi.nlm.nih.gov/21616125