0000000000920645

AUTHOR

Lucía Galán

showing 4 related works from this author

Clinical and therapeutic features of myasthenia gravis in adults based on age at onset

2020

[Objective] To describe the characteristics of patients with very-late-onset myasthenia gravis (MG).

AdultMalePediatricsmedicine.medical_specialtyThymomagenetic structuresCross-sectional studyInvestigación médicaEnfermedad del sistema nerviosoMEDLINEMiastenia gravisLate onsetDISEASECLASSIFICATIONArticleACETYLCHOLINE-RECEPTOR03 medical and health sciences0302 clinical medicineimmune system diseasesMyasthenia GravismedicineEnfermedades neuromuscularesHumansRITUXIMAB030212 general & internal medicineAge of OnsetAgedbusiness.industryAnálisis de datosMiddle Agedmedicine.diseaseMyasthenia gravisnervous system diseasesCross-Sectional StudiesTreatment OutcomeMulticenter studyANTIBODIESAUTOANTIBODIESFemaleObservational studyNeurology (clinical)Age of onsetbusiness030217 neurology & neurosurgeryMUSK
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Amyotrophic lateral sclerosis modifies progenitor neural proliferation in adult classic neurogenic brain niches.

2017

Background Adult neurogenesis persists through life at least in classic neurogenic niches. Neurogenesis has been previously described as reduced in neurodegenerative diseases. There is not much knowledge about is adult neurogenesis is or not modified in amyotrophy lateral sclerosis (ALS). All previous publications has studied the ALS SOD1 (superoxide dismutase) transgenic mouse model. The purpose of this study is to examine the process of adult neurogenesis in classic niches (subventricular zone [SVZ] and subgranular zone [SGZ] of the dentate gyrus) in patients with amyotrophic lateral sclerosis (ALS), both with (ALS-FTD) and without associated frontotemporal dementia (FTD). Methods We stud…

0301 basic medicineMalePathologymedicine.medical_specialtyDoublecortin ProteinTDP-43NeurogenesisSOD1Subventricular zoneAdult neurogenesislcsh:RC346-429Subgranular zone03 medical and health sciences0302 clinical medicineNeuroblastNeural Stem CellsLateral VentriclesMedicineHumansAmyotrophic lateral sclerosislcsh:Neurology. Diseases of the nervous systemAgedAged 80 and overbusiness.industryDentate gyrusNeurogenesisAmyotrophic Lateral SclerosisNeurodegenerative diseasesBrainGeneral MedicineMiddle Agedmedicine.diseaseNeural stem cellnervous system diseases030104 developmental biologymedicine.anatomical_structurenervous systemFrontotemporal DementiaFemaleNeurology (clinical)business030217 neurology & neurosurgeryResearch ArticleBMC neurology
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Subventricular zone in motor neuron disease with frontotemporal dementia.

2011

Investigate how the subventricular proliferation and organisation is modified in a patient with FTLD-ALS. We studied the subventricular zone (SVZ) of a patient with FTLD-ALS immunohistochemical and histologically. We found an increase of Ki-67 positive cells and neuroblast in the subventricular zone, suggesting an activation of proliferating activity in response to FTD-ALS. This proliferation can act as a compensatory mechanism for rapid neuronal death and its modulation could provide a new therapeutic pathway in ALS. These results suggest a modification of neurogenesis in FTD-ALS. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

TelencephalonSubventricular zoneanimal diseasesNeurogenesisSubventricular zoneBiologyFrontotemporal lobar degenerationNeuroblastNeural Stem Cellsmental disordersmedicineHumansMotor neuron diseaseAmyotrophic lateral sclerosisMotor Neuron DiseaseAgedGeneral NeuroscienceNeurogenesisAmyotrophic Lateral Sclerosisnutritional and metabolic diseasesFrontotemporal lobar degenerationMotor neuronmedicine.diseaseNeural stem cellnervous system diseasesmedicine.anatomical_structurenervous systemFrontotemporal DementiaNerve DegenerationFemaleAmyotrophic lateral SclerosisNeuroscienceFrontotemporal dementiaNeuroscience letters
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Additional file 1: Table S1. of Amyotrophic lateral sclerosis modifies progenitor neural proliferation in adult classic neurogenic brain niches

2017

Antibodies used in the immunohistochemical study. Table S2. Summary of patient characteristics. Table S3. Immunohistochemical studies used in ALS diagnosis. Values for TDP-43 and ubiquitin are expressed in inclusions per field; %pTDP-43 represents the percentage of phosphorylated TDP inclusions out of the total. Table S4. Description of neurogenesis patient to patient. Table S5. Neurogenesis findings in the subgranular zone of the hippocampal dentate gyrus, by patient. Table S6. Summary of results in the SVZ. Table S7. Summary of results in the hippocampus. (DOC 302 kb)

nervous system
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