0000000001258224
AUTHOR
Pilar Prieto
showing 8 related works from this author
Sobre alguns contrastos fonològics en l'entonació del català
2021
The main goal of this article is to provide evidence in favor of the phonological character of some intonational contrasts in Catalan. First, the article shows that tonal alignment differences with respect to metrically strong positions are crucial for the distinction between a yes-no question and a wh-question (cf. "¿Que l’ha llogada?" vs. "¿Qui l’ha llogada?") and between a command and a request ("¡Vine!" vs. "¡Vine!") in Central Catalan. Second, the article reports the major results from the application of the Categorical Perception Paradigm to a pitch height contrast in Majorcan Catalan (Vanrell 2006a). Experimental resuls show that a small variation in the pitch height of the pretonic …
The beaker phenomenon and the Genomic transformations of Northwest Europe
2018
Bell Beaker pottery spread across western and central Europe beginning around 2750 BCE before disappearing between 2200–1800 BCE. The mechanism of its expansion is a topic of long-standing debate, with support for both cultural diffusion and human migration. We present new genome-wide ancient DNA data from 170 Neolithic, Copper Age and Bronze Age Europeans, including 100 Beaker-associated individuals. In contrast to the Corded Ware Complex, which has previously been identified as arriving in central Europe following migration from the east, we observe limited genetic affinity between Iberian and central European Beaker Complex-associated individuals, and thus exclude migration as a signific…
An exploratory study of two Caco-2 cell models for oral absorption: A report on their within-laboratory and between-laboratory variability, and their…
2010
In 2005, the European Centre for the Validation of Alternative Methods (ECVAM) sponsored a study aimed at evaluating the reproducibility (between-laboratory and within-laboratory variability) and the predictive capacity of two in vitro cellular systems — the Caco-2/ATCC parental cell line and the Caco-2/TC7 clone — for estimating the oral fraction absorbed (Fa) in humans. Two laboratories, both of which had experience with Caco-2 cultures, participated in the study. Ten test chemicals with documented in vivo oral absorption data were selected. Atenolol, cimetidine and propranolol were included as reference compounds for low, medium and high intestinal absorption, respectively. Transport ex…
Use of flow cytometry and confocal microscopy techniques to investigate early CdCl(2)-induced nephrotoxicity in vitro.
2001
CdCl(2) is a well-known toxic compound for the kidney in vivo and in vitro. We report here part of the results of an ECVAM (European Centre for the Validation of Alternative Methods) contract study, aimed at establishing and assessing several flow cytometric and confocal microscopic endpoints for use in an in vitro nephrotoxicity model. Three renal tubule cell lines, OK (opossum, proximal tubule origin), LLC-PK1 (pig, proximal tubule origin) and MDCK (dog, distal tubule origin) were exposed for 1, 5 and 24 h to 25 microM and 100 microM CdCl(2). The results obtained for mitochondrial membrane potential showed a decrease in all the cell lines after 5 h of treatment with both CdCl(2) concentra…
Comparative analysis of eight cytotoxicity assays evaluated within the ACuteTox Project.
2013
A comparative analysis of eight cytotoxicity assays [the 3T3 and normal human keratinocytes Neutral Red Uptake (NRU) assay, the primary rat hepatocytes, human HepG2 and 3T3 MU assay, and the human A.704, SH-SY5Y and HepG2 cells propidium iodide (PI) assay] included in several work packages of the EU Integrated Project ACuteTox, has been carried out. The aim was to evaluate whether cells originating from liver, kidney and brain provided different in vitro acute toxicity results, and the influence of primary liver cells versus cell lines originated from the same tissue. Spearman rank correlation analysis and Hierarchical Cluster Analysis were performed based on the IC50 (50% inhibitory concen…
L'atles interactiu de l'entonació del català i el traçat de les isoglosses entonatives del català
2010
En la primera part d’aquest article presentem el projecte de l’"Atles interactiu de l’entonació del català", que té com a objectiu la presentació d’una sèrie de materials en àudio i en vídeo per a l’estudi de la prosòdia i l’entonació dels dialectes catalans. En la segona part expliquem els primers resultats geoprosòdics que s’han obtingut a partir de l’anàlisi de diferents tipus de patrons entonatius de l’"Atles", tot iniciant el traçat de les isoglosses prosòdiques en el domini lingüístic català. Per una banda, veurem que hi ha contorns entonatius que són molt generals a tot el domini, com ara els contorns de les frases declaratives neutres i els de les declaratives que expressen un senti…
Entonació i pressuposició en les interrogatives absolutes del mallorquí
2010
Aquest treball investiga de quina manera l’entonació reflecteix el diferents graus de coneixement del parlant en les interrogatives absolutes del mallorquí. Mitjançant tres experiments de percepció (un test d’adequació, un test d’avaluació i un test d’identificació basat en el paradigma clàssic de la percepció categorial) s’ha pogut demostrar que els oients catalans distingeixen quan el parlant no té ni idea de quina serà la resposta de la pregunta que està produint de quan el parlant té certes hipòtesis sobre quina hi serà la resposta i cerca confirmació d’aquestes hipòtesis. També s’ha pogut comprovar que les interrogatives manifesten una gradació de coneixement del parlant a l’hora de pr…
L'expressió de la incredulitat en català: un estudi prosòdic
2010
Aquest article pretén aprofundir en l’anàlisi entonativa de les oracions interrogatives absolutes informatives i les que denoten incredulitat en català. En la primera part expliquem els primers resultats geoprosòdics, els quals s’han obtingut a partir de l’anàlisi de les oracions interrogatives absolutes neutres i les interrogatives absolutes que denoten incredulitat de l’"Atles interactiu de l’entonació del català", tot iniciant el traçat de les isoglosses prosòdiques en el domini lingüístic català. En la segona part de l’article presentem els resultats d’un experiment de percepció en català central que pretén investigar quins trets prosòdics són els que calen als parlants per a distingir …