Electrostatically Driven Complexation of Liposomes with a Star-Shaped Polyelectrolyte to Low-Toxicity Multi-Liposomal Assemblies

Anionic liposomes are electrostatically complexed to a star-shaped cationic polyelectrolyte. Upon complexation, the liposomes retain their integrity and the resulting liposome-star complexes do not dissociate in a physiological solution with 0.15 M NaCl. This provides a multi-liposomal container for possible use as a high-capacity carrier.