Analisi dei meccanismi di controllo dell’apoptosi in una linea cellulare β-pancreatica resistente all’effetto delle citochine.

Visceral adiposity index is associated with significant fibrosis in patients with non-alcoholic fatty liver disease

Background: Metabolic factors have been associated with liver damage in patients with non-alcoholic fatty liver disease (NAFLD). Aims To test a new marker of adipose dysfunction, the visceral adiposity index (VAI), in NAFLD patients to assess whether or not it is associated with host factors, and to investigate a potential correlation with histological findings. Methods One hundred and forty-two consecutive NAFLD patients were evaluated by liver biopsy, and clinical and metabolic measurements, including insulin resistance with the homeostasis model assessment (HOMA), and VAI by using waist circumference, body mass index, triglycerides and HDL. Serum levels of TNFα, IL-6, adiponectin and lep…

Le tireopatie autoimmuni

Insulin sensitività in women whit clinical features of hyperandrogenism.

Effetti di un’infusione insulinica di breve durata in diabetici tipo 2 non obesi in “secondary failure” alle sulfaniluree.

Up-regulation of c-FLIPshort and reduction of activation-induced cell death in T-cells from patients with Type 1 diabetes

AICD of T-cells is an efficient way of removing activated T-lymphocytes. In this study we investigated the molecular basis of AICD upon reactivation in peripheral T-lymphocytes from newly diagnosed T1DM patients and age-matched healthy controls. In an in vitro model system, PHA-stimulated T-cells, upon prolonged culture in IL-2, acquire a sensitive phenotype to Fas-mediated apoptosis. This phenomenon is less pronounced in T1DM T-cells. Moreover, the restimulation of activated T-cells via TCR/CD3 and/or via CD28 inhibits Fas-mediated apoptosis in T1DM in comparison to control T-cells. After Fas triggering, the generation of the active sub-units of caspase-8 is significantly reduced in T1DM T…

Detection of BRAFV600 mutation in papillary thyroid carcinoma using real time allele-specific amplification on fine needle aspiration biopsy specimens

MARKERS OF INFLAMMATION AND PREVALENCE OF VASCULAR DISEASE IN PATIENTS WITH METABOLIC SYNDROME

AIM: The aim of this study was to determine the prevalence of carotid atherosclerosis and coronary heart disease and cerebrovascular disease in subjects with metabolic syndrome and to investigate the relationship between atherosclerosis and C-reactive protein (CRP) levels. METHODS: We studied 568 ambulatory subjects, referred to our Center for the study of atherosclerosis and cardiovascular prevention by general practitioner, for the presence of traditional cardiovascular risk factors. Subjects were divided in two groups: those with metabolic syndrome (n=163), and those with 0-2 metabolic abnormalities (n=405). All subjects underwent carotid artery ultrasound and blood tests including high …

Efficacia e sicurezza della terapia con glargine in gravidanza: esperienza su una casistica di 15 donne diabetiche di tipo 1.

Alterazioni del metabolismo glucidico determinate da eccesso di ormoni controregolatori: ruolo del GH

The abnormal hepatic morphology: not always cirrhosis

Learning objectives Background Findings and procedure details Conclusion Personal information References

Use of basal insulin analog detemir in pregnant women with type 1 diabetes: a case-control retrospective study

Valutazione dell’insulinoresistenza tramite un test pasto standard.

AlKam Metabolic Syndrome Study (AlkaMeSy Study): Studio di prevalenza sulla sindrome metabolica.

Hirsutism and oligomenorrhea are characterized by a different pathogenesis in women affected by PCOS

Janus kinase (JAK) 2 V617F mutation as the cause of primary thrombocythemia, severe visceromegaly and divergence between growth hormone and insulin-like growth factor-1 concentrations in acromegaly due to a therapeutically resistant pituitary GH-secreting macroadenoma